Otezla pro plaque psoriasis skyrizi

Inverse and plaque psoriasis together

2023.06.04 21:44 Melodic-Translator45 Inverse and plaque psoriasis together

Hiya y'all. The labs just came back to confirm that I have both types. I'm seeing the derm to start biologic soon. My question is about the inverse psoriasis which troubles me way more than the plaque because I'm fat and it's all under my boobs and in my groin. I'm wondering if other people have both and how they handle it. Also will the areas that crust, crack and bleed scar permanently?
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2023.06.04 20:43 SweetBoy3D Otezla and Alcohol

24M here, just got started on Otezla ~7 weeks ago for my moderate plaque psoriasis. I’ve had some unpleasant gastrointestinal side effects that still haven’t fully subsided, but my skin is already starting to clear up in a pretty miraculous way.
Anyway, that’s not what I’m here to talk about today. I’m curious if anyone else has noticed a bizarre shift in their relationship with alcohol while taking Otezla.
I drink every weekend, often socially but sometimes just to unwind. I’m as happy to be out at a bar with friends as I am to be posted up on the couch with a six-pack watching basketball. Long story short, I like to drink and it’s a consistent part of my weekly routine.
Since starting on Otezla, though, drinking simply… doesn’t feel as good? It’s hard to pin down and describe exactly what about the experience is diminished, but essentially it’s just not as fun to be be drunk anymore. Makes me more headachey, maybe. I feel like even the taste is less appealing than it once was.
I’ve read online that apremilast is undergoing clinical trials for treatment of alcohol use disorder, after early findings that it was effective in curbing excessive alcohol consumption, so I guess my experience makes sense. The research only mentioned subjects’ reduced cravings while on the drug, though, nothing about its effect on the experience of drinking itself.
Just wondering if others have had a similar experience with this drug, can’t seem to find any discussion online re: this strange side effect. Personally I’m not complaining lol, I don’t think alcohol is a net positive on most people’s lives, myself included. I’ll probably just take this as an opportunity to cut down. Still, not a side effect I was expecting to say the least!
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2023.06.04 03:46 jaysonm007 What is a good moisturizer for scalp psoriasis?

My scalp psoriasis is dying down to the point where I don't have to use topical steroids. Now my scalp just seems really dry with very few raised plaque patches. I would like to try a moisturizer. I know of vaseline/petroleum jelly for the areas just outside the hair but what works on the scalp itself?
I don't mind if my hair looks a bit greasier just as long as it isn't absolutely ridiculous (like I know I can't use Vaseline as it would look crazy). So if it makes me look like a greaser from the 1950's that is okay -- I just want to get rid of this. Any suggestions?
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2023.06.03 20:34 MajestaMajorca An article today about possible "causes."


"Among the study’s surprising findings were increased genetic activity in dozens of molecular pathways associated with the control of metabolism and lipid levels, which are associated with the development of diabetes and cardiovascular disease.
“Our molecular cartography unexpectedly revealed that even skin areas far away from plaques that look healthy have profound changes in their cellular and molecular makeup,” Dr. Naik explained."
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2023.06.03 20:32 MajestaMajorca Science paying a little more attention, maybe?

"Among the study’s surprising findings were increased genetic activity in dozens of molecular pathways associated with the control of metabolism and lipid levels, which are associated with the development of diabetes and cardiovascular disease.
“Our molecular cartography unexpectedly revealed that even skin areas far away from plaques that look healthy have profound changes in their cellular and molecular makeup,” Dr. Naik explained."
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2023.06.03 16:04 SeaAwareness3650 Celebrex --> Otezla --> Humira --> ???

I was diagnosed with PsA a couple years ago after being told for many years that I had osteoarthritis + eczema. I had a hip replacement at age 40 and kept asking, "How do I have such severe osteoarthritis at such a young age?" Whenever I asked about possibly having autoimmune arthritis, I was always told no. Since then I've had the second hip replaced and, due to increasing pain (especially in my left heel, elbow, both feet, hands) and horrible "eczema", I was finally diagnosed with PsA. I'd been on Celebrex for years for the "osteoarthritis", then after the PsA diagnosis they added Otezla. Otezla didn't seem to help at all, and it gave me insomnia. So the rheum switched me to Humira. Humira cleared up my worst skin issue by about 50%, but it didn't do much for my joint pain and it made me feel awful. The day of the shot I had to prepare for at least two more days of severe exhaustion. After three months on Humira I developed an intestinal issue (bloodwork all came back normal, no c-diff, no parasite, no salmonella) that they still don't understand, and I had to stop the Humira during that time because I was put on an antibiotic. Now I don't want to restart the Humira, because TBH I feel better without it. I do need to take something, though, so hoping there's a med that will give me relief.
For me the heel/foot pain and fatigue are the worst aspects of this disease so far, and my scalp psoriasis is extreme to the point where I have scabs under my hair everywhere (prescription shampoo doesn't help much). I am not working and left my last job because the stress caused flares so bad I could barely use my hands. I can't stand up for long periods, I can't sit for long periods (because when I stand up I can barely walk), and I can't use my hands all day (i.e., typing) either, especially if under stress. It's very difficult to find a job I can physically handle.
I guess there isn't really a question here, just venting and hoping for a better med.
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2023.06.02 19:28 LaGrippeResearchAlex Mild Psoriasis (PsO) Research Project

My name is Maggie and I am with LaGrippe Research, a market research firm specializing in healthcare. We are currently inviting individuals diagnosed with Mild Plaque Psoriasis (PsO) to participate in our upcoming discussion and want to see if you would be interested.
This will be in the form of a 2-part project. The first will be a 60-minute discussion with our moderator the week of June 26th, followed by a 2-day online community that will take place the week of July 10th. For participating in BOTH parts, you will be compensated $150 as a thank you. Payment for participating in both parts will be processed after the second part has been completed.
If you are interested, please fill out our preliminary questions online here: https://www.surveymonkey.com/PFJCKR3
If you have any questions, please contact Maggie at 847-373-4104 or email [[email protected]](mailto:[email protected])
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2023.06.02 18:05 Student_Ok Changing services connected disability due to misdiagnosis during active duty

While active duty, I was diagnosed with dermatitis. I got that service connected at 0%. I still have this same rash but now it's worse. Through VA community care, my dermatologist is saying it's actually plaque psoriasis.

Has anybody ever been misdiagnosed while active duty and had to change their service connected disability afterwards?
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2023.06.02 14:57 Killercurvez Low LDL

I applied for life insurance and everything came back great except my LDL. It's 61mg/dl, but the chart shows the normal range to be between 80-200. Am I at risk for a heart attack? Google is scaring me. I attached the lab results.
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2023.06.01 20:48 jigeshapunj31 Plaque Psoriasis Medication

Used propysalic for my Plaque Psoriasis but it left very dark scars around my feet up to my ankle I used propysalic for plaque psoriasis in my feet, it did get a little better but it left a very bad pigmentation all around my feet up till my ankle. It was quite dark and that darkened skin felt like dead skin that I could just peel off. Any idea what exactly happened? and How should I tell this to my derma?
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2023.06.01 16:37 ExaltFibs24 Toothpaste hack for one bag.

I tried three different toothpaste options for the most efficient tooth brushing and packing lightly for OneBag. The surprise winner turned out to be the cheapest here in India!
  1. Uber popular toothpaste tablets. The standard size of the tablet is way too much for my regular toothbrushing, a needless waste. For the uninformed, toothpaste should be used as least as possible, just like washing powder. PLUS, a small can of toothpaste tablet weighed more than a small toothpaste in tube. Also note that ADA (American Dental Association) DO NOT recommend them, plus most of these tablets have no fluoride, which means no protection against cavities. I also find it taking longer time; you need to chew these tablets like a gum for a minute or so before even starting to brush. Only advt I see is minimizing plastic waste.
  2. Toothpaste in a tube is second best. It let me squeeze out the paste to my liking, unlike tablets. Biggest complaint I have is plastic waste.
  3. The best of the three options I found was toothpowder, very popular in days of yore sweet 1980s), like this Buy Colgate Cavity Protection Toothpowder - with Calcium and Minerals for Anti-Cavity - 200 g Online at Low Prices in India - Amazon.in. For those who realize that aqua in shower gels is just a fancy term for water (and shower gels is a scam compared with a bar of soap), toothpowder lasts way longer than standard toothpaste and toothpaste tablets. Btw the science says toothpowder is more efficient in removing plaques than toothpaste, an example peer-reviewed paper here: Comparison of the plaque-removing efficacy of toothpaste and toothpowder - PubMed (nih.gov)
I carry toothpowder in a small 30ml airtight plastic container, and I dip a slightly wet toothbrush (I use Philips Sonicare) in it. 50g toothpowder easily lasts three months for me with twice daily brushes, vastly exceeding 50g toothpaste that hardly lasts a month. Lasting much longer means fewer trips to the grocery store and less plastic waste (June 5th, World environment day coming in 4 days, this year's theme is plastic pollution!)
Pro Tip: I never wash my mouth after brushing (You should do this too). This helps to provide leftover fluoride to my tooth. No watemeals for the next 1 hour.
Hope this helps.
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2023.06.01 15:10 downinthedumps99 Was told I have gingivitis but no presence of plaque/calculus, what else could it be?

I had a dental examination with a new dentist earlier today. They took x rays, probed my gums, ruled out decay ect. They said that the measurements around the 6's are a little deeper than the others but still within the scale of not being a concern.
They did say though that I have gingivitis but no presence of plaque or calculus, even on the x rays. They've said to keep up with the meticulous hygiene I'm keeping and to try different methods of flossing to see what might help, if anything.
I do have psoriasis which is autoimmune related and they said it might be linked. Could the two really be linked?
Thank you in advance!
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2023.06.01 07:30 BagOk4379 Understand Psoriasis and its few Major Types

A chronic, non-contagious autoimmune illness called psoriasis is characterized by elevated, abnormal skin patches. These spots are scaly, dry, irritating, and red, pink, or purple in color. The extent of psoriasis can range from small, localized patches to total body coverage. A persistent skin condition caused by an overactive immune system, psoriasis is frequently distinguished by thick, red skin and silvery plaques.
Although it resembles a rash, psoriasis is not communicable. It takes a month for normal skin cells to develop and shed. However, in the case of psoriasis, skin cells multiply more quickly, piling up on the skin rather than shedding and resulting in plaques that may be annoying, painful, and itchy.
The five main kinds of psoriasis are erythrodermic psoriasis, pustular psoriasis, guttate psoriasis, inverse psoriasis, and plaque psoriasis. Other psoriasis types include; scalp psoriasis, psoriatic arthritis, psoriasis vulgaris, nail psoriasis, and genital psoriasis.
  1. Erythrodermic Psoriasis. The least frequent kind of psoriasis is erythrodermic. But if untreated, it can become serious and even fatal. It results in widespread skin scaling and reddening over substantial body portions. An infection, a bad sunburn, or using certain drugs like corticosteroids or lithium may cause this kind of psoriasis.
  2. Guttate Psoriasis. Small (less than 10 mm in diameter) circular, raised, red skin patches covered in a thin scale are the characteristics of guttate psoriasis. It frequently manifests suddenly after an infection like bronchitis or strep throat. Within a few weeks or months, this type of psoriasis frequently goes away without treatment.
  3. Inverse psoriasis. In the folds of skin, such as the armpits or groin, inverse psoriasis manifests as red, smooth patches of skin. Those who are overweight are more likely to experience it. Due to changes in hormone levels, pregnancy frequently impacts women. Wearing tight-fitting clothing might cause friction and moisture, aggravating inverse psoriasis.
  4. Pustular psoriasis. White or yellow pimples packed with pus on a red base characterize pustular psoriasis. These lesions can manifest as little, localized rashes or large, dispersed regions. It most frequently affects adults. Usually, drugs, infections, stress, or exposure to specific substances will cause it.
  5. Plaque psoriasis. The most typical type of the condition is plaque psoriasis. Raised, red areas that are covered in a layer of dead skin cells that is silvery-white are its defining features. Plaques are another name for these patches. Their diameter might range from a few millimeters to many centimeters.
  6. Psoriatic Arthritis. 1-2% of people have psoriatic arthritis, a kind of autoimmune inflammatory arthritis. Patients with it may have psoriasis or, in rare instances, not, although they typically have a family history of the condition. Men and women have the exact prevalence of psoriatic arthritis (PsA), but women have a higher disease burden and more frequently develop polyarthritis.
Patients are far more likely to get psoriatic arthritis symptoms if they have a parent, child, or sibling who has the condition. It can manifest as various joint involvement patterns, frequently asymmetrical joint involvement, and occasionally with soft tissue swelling of the finger or toe (which makes them look like sausages). Back discomfort with inflammation is another side effect.
Bharat Homeopathy’s homeopathic treatment for psoriasis is increasingly becoming popular in providing psoriasis treatment. With numerous success stories of patients being cured, the hospital has become the patient’s foremost choice. It helps people with the illness live better lives and control their symptoms. The degree of psoriasis, its location on the body, and the patient's response to various medicines all influence the treatment option.
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2023.06.01 06:41 oceanalwayswins [<1F] What are these episodes? Doctors are stumped and they are getting worse.

Age: 7 months
Sex: female
Weight: unsure, medical team has no concerns with her growth or size
Location: US
I am posting on behalf of a close friend. Her 7 month old daughter began having concerning episodes and symptoms at around 3 months. These symptoms have been persistent and are gradually increasing in frequency and severity.
Videos of episodes - Video 1 / Video 2
MRI results - MRI Results
Lab results - Labs page 1 / Labs page 2
Episodes last anywhere from 10 seconds to 1 minute. These episodes consist of her bending her legs, stiffening her body and squeezing her head. More often than not she rolls her eyes or has a blank stare.These episodes only occur when laying down, only when awake (not while sleeping). Does not happen when propped up. Baby will stop playing and nursing when these episodes begin. They are happening more often, and “sometimes 10 times in a row”. Some are mild while others are severe.
Her pediatrician says he has never seen anything like this, and is consulting with another pediatrician outside of the US. ENT and Ophthalmologist both say everything is fine in regards to their specialties. Neurologist had no idea and said to follow up in a few months. EEG’s (2-day and 2-hr) and MRI were normal. Many of these episodes have been caught on EEG and they say these are not showing as epileptic seizures. Blood work shows a few components that are a little high/low.
Physical therapist has diagnosed her with hypotonia. She has gross motor delays. Rolled over at 6.5 months, not yet sitting up. Previously struggled with tummy time and would scream during, but is now doing better at being on her stomach than rolling.
Baby is eating well, gaining weight. She’s a happy baby but quiet. She’s crying much less than she was, but is also does not babble most days. Mother says she is “weirdly quiet”. Breastfeeding and eating baby foods well, but is not picking up foods (like baby puffs). Very interested in toys and plays with and chews on them.
Mother had Covid at 6 months gestation. Baby had Covid at 2 months of age. Mother does not know APGAR score. She was born 3 weeks early. Baby was not crying at birth. Otherwise normal pregnancy and baby is the mother’s third child (first child for her father). Mother is in her early 30’s, active, healthy. Was taking Otezla for psoriasis and Wellbutrin when she conceived, stopped taking both at around 4 weeks gestation. Father spent one tour in Iraq for Operation Iraqi Freedom, Infantry Airborne.
She sees the neurologist again next week. My friend is desperately seeking any information or suggestions. Thank you!
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2023.06.01 00:32 No_Bodybuilder5020 I've had many, MANY times where I've scratched, and dug HARD into my plaques, making them bleed all over , while I had dirty, nasty, uncleaned hands with whatever on them - can this cause sepsis? I have had severe psoriasis for years, it's hard not to cave to temptation to pick/scratch

It came to me one day that I may have sepsis and not even know it. I actually didn't know what sepsis was for a long time. After I had learned what it is, months later, I get hit with the 'oh SHIT' moment of holy fuck, is it possible I have sepsis?

I definitely haven't engaged in solo adult activities while having an active infection down there seconds prior to doing this, too, no, not at all, I'm not gross like that... at all
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2023.05.31 22:23 bowdry Not sure what to do now

Got prescribed Skyrizi (which insurance initially denied and took 2 months to finally appeal) and finally went to my dermatologist to be shown how to administer the pen. My clinic has rotating doctors so I got attended to by someone I don’t usually see and she didn’t want to administer it 🥲 She said I had high liver enzymes and sent to to get blood work again.😩 But I don’t drink neither am I obese, my diet is pretty good and I exercise regularly. I know psoriasis may affect other organs so could it be related? If my blood work results are the same what do I do if she denies my meds again?
I’ve had a bad flare up caused by covid back in January and I just can’t be slathering Clobetasol like lotion anymore.. Also considering to reschedule my appointment so I can see my usual dermatologist
Sorry for the ramble, my mind is all over the place
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2023.05.31 20:57 Marcus2Ts For those who switched to Skyrizi from another biologic, we're there any barriers/difficulties to doing so?

I've been on Humira for around 5 years. My joints are doing pretty good and my nails have been basically clear since I've been on it but the skin psoriasis doesn't seem to respond to Humira like it used to (I've been flared up for a little over a year).
Getting on Humira in the first place was a nightmare since I had to first try cheaper, ineffective treatments (a whole year on Methotrexate that I'd like to forget). I'll be asking my rheumatologist about Skyrizi during my June appointment. So, I'm wondering if folks have found the process of switching medications to be much of a hassle with your insurance.
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2023.05.31 20:46 livelaughpraylove Nothing i eat affects my psoriasis

So i got guttate last november of 2022 from a strep infection. It was horrible at first, little spots all over my body like chicken pox. A few months of hoping it would go away, i eventually went to get some ointments which did nothing,then phototherapy. Phototherapy helped. After my dermatologist thought we should stop bc it wasnt working, i went on otezla for 3 months which did nothing either. I finally decided to go on the pagano diet which a lot of people say completely made their psoriasis go into remission. And actually i kind of am starting to see what those people mean. The redness is going down, the itchiness is virtually gone, and slowly my spots are disappearing. However, one of the main ideas behind his diet is the assumption that people who have psoriasis have a leaky gut and removing foods from the diet allows the body to heal itself. He also talks about removing foods that you in no way should eat, such as sugar and nightshade plants. Well, i was on this diet for a good 3 weeks or so. Then memorial day came around and i decided to do a little experiment. I ate pretty much all the foods he says not to eat and it even seems like my psoriasis is improving still !! What does this even mean? Knock on wood, but no flares, nothing. Im completely and utterly confused. I mean im going to start back on the diet tomorrow but it seems im not affected by these food groups. Idk i hate this. I have a rx for skyrizi and want to take it but I don't want to at the same time..oh and i never had psoriasis before i got strep.
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2023.05.31 18:00 misspinesol Nail/scalp changes - advice?

Nail/scalp changes - advice?
Hi all - I'm currently diagnosed with spondyloarthritis, but have had symptoms of AS/PsA over the years. I'm in a month-long flare of knee pain (bilateral) and am experiencing weird skin/nail things, which is leading me to wonder whether it could be psoriasis? Can anyone who has this let me know if it looks similar?
In the photos, you can see that my big toenail has ridges and is flaking (both feet), and my second toenail is cracked and falling off (this happened on both feet, same nail). I have itchy red bumps on my scalp and swaths of flaky white areas, but no visible plaques.
I see my rheum in June and want to be prepared - any suggestions about what to discuss are also appreciated!
Brief history:
- Spondyloarthritis diagnosis - 2021- Currently taking sulfasalazine (I got lazy with doses last month and wonder if that's why I'm flaring)- HLAB-27 positive- Recurrent uveitis (~once a year)- ANA is only abnormal blood marker- Recent MRI showed previous bilateral damage to SI joint but no active inflammation

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2023.05.31 13:35 Neoskinclinic Anti dandruff hair care Neoskin CLinic

Anti Dandruff Treatment In Hyderabad

Anti Dandruff : Anti Dandruff treatment in Hyderabad: Scalp is one of the most sensitive regions of the body with all forms of weather playing havoc. Dandruff is a condition in which the skin cells present on the scalp are produced in excess amount, causing itching and irritation. The scalp becomes scaly, dry and itchy. Dandruff is also called as seborrhea dermatitis, causes symptoms like skin lesions, plaques, mild redness, etc.
Dandruff mainly occurs due to secretion of sebum glands, certain microorganisms and depressed immune system. It also arises due to metabolic imbalance of the body and lack of proper diet and nutrition required for hair. It is also caused due to allergy reaction caused by sprays, shampoos, gels, hair oils etc.
Anti Dandruff treatment in Hyderabad Apart from being a cosmetic problem of hair, Dandruff also diminishes a person’s self esteem and social acceptance levels due to the unsightly appearance of flexes on scalp and exposed portions of hair, continuous itching and flake deposition onto a person’s shoulder.
neoskin employs advanced formulations, technology, time tested and clinically approved medications to treat Dandruff and the resulting symptoms.
Customized Anti-dandruff programs @ neoskin has transformed the lives of scores of denizens in this region from various walks of life and has contributed its part for healthy and confident lives, eliminating the problem which was otherwise considered a bane and a never ending irritant.

Causes Of Dandruff

Irritated Oily Skin:
If you have greasy oily scalp, you should shampoo more frequently. The fungus Malassezia Globosa feeds on natural oils on our scalp and produces oleic acid as a byproduct; many of us are sensitive to this byproduct. Our sensitivity to it causes our immune system to respond, resulting in dandruff.
Hormones: Sebum, natural oils found in your scalp, face, and other parts of your skin, are required for the production of dandruff in your scalp. Hormones Cause The Oil Produced In Your Scalp That The Yeast (Fungus) Malassezia Feasts On To Cause Dandruff. This is also why people experience their first bouts of dandruff during puberty. Puberty causes an increase in hormones, which causes an increase in oil, which causes an increase in dandruff.
Food: Food defines us in every way imaginable. It is not only responsible for how our bodies look and function, but it also contributes to the health of our scalp and hair. Excess sugar, refined sugar, and bad fats can cause an increase in insulin, which can trigger more hormone production, resulting in oil production and a severe dandruff problem.
Stress: We’re All Aware That Excessive Stress Isn’t Good For Anyone, Mostly For Psychological Reasons, But It Has Other Consequences As Well. Stress Is Not Good, Especially If You Have Dandruff. While Malassezia Globose, the cause of dandruff, does not appear on the scalp as a result of stress, it does outgrow as a result of it. Stress weakens your immune system, compromising your scalp. This causes more dandruff, which increases your stress and causes more dandruff, and this vicious cycle continues.
These are the most common causes of severe dandruff, but there are risk factors that can increase the likelihood of having dandruff.
The causes of dandruff vary from person to person, but it is usually a result of improper handling of hair and scalp. According to experts, the cause of dandruff is rapid maturing and shedding of scalp cells precipitated by excessive oil secretion.

Photo facial: Chemical Peel Treatment in Hyderabad

Broadly speaking, the causes can be categorised into:

1. Microorganisms
A: fungus infection
One of the most common causes of dandruff is Malassezia, a fungus. It has been shown to stimulate the lipase enzyme, which is responsible for the production of saturated and unsaturated fats. While saturated fats promote fungal cell growth and division, unsaturated fats cause skin inflammation and irritation. Furthermore, it alters the normal shedding of dead cells, resulting in visible white flakes.
B) Bacterial infection
Propionibacterium acnes and Staphylococcus epidermidis are two bacteria that can be found on the scalp and cause dandruff.
2. Non-microbial factors

Dandruff Risk Factors :

If you have dandruff, you are more likely to have it if: 1. Age Dandruff usually appears during adolescence and lasts until middle age. That isn’t to say that older people don’t get dandruff. For some people, the problem can last a lifetime. 2. Being male Dandruff is more prevalent in males than in females.
  1. Specific chronic illnesses Parkinson’s disease and other nervous system diseases appear to increase the risk of dandruff. Having HIV or a weakened immune system also contributes to this.
  2. Other circumstances
Fatigue and stress Your scalp is oily. Even when your scalp is not dry, you experience intense itching. Most of the time, your hair appears greasy. You’re not brushing your hair properly. Leaving oily hair alone Using abrasive shampoo Excessive use of styling tools
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