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2010.05.19 17:23 Tarasosx Otters: For all your otter needs

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2023.06.09 10:23 summitmedical Colorado Springs' Best Rehabilitation Centre

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2023.06.09 10:14 communist-crapshoot The Claires *are* social democrats *not* secret communists and seizing the harbor was not in itself a revolutionary act. It's long past time fans stop lying to themselves and start engaging with the Marxist "ruthless criticism of all that exists" at the core of the game, as was always intended.

Let me preface this lecture by stating that I *am* a communist and have been for over a decade and that before I can get into what I think the Claires are supposed to represent I need to address why Kurvitz & Co. chose a videogame as the preferred medium for their metafiction. The reason Disco Elysium was made the way it was wasn't simply to entertain people with the funny antics of an alcoholic, superstar, hobo cop or to strive towards critical acclaim so the game would sell better. It wasn't even a game made by communists for communists (I mean it was made by communists it's just not preaching to the choir as much as some might think). In fact it's quite the opposite. The story was injected with nihilistic humor and offered up to the general public in the form of a video game to sugar the pill so to speak. That's because Disco Elysium is, at its core, a highly controversial political treatise and social critique "disguised" as a video game. This was so as to get as many people as possible to actually engage with its core messages instead of reflexively rejecting or ignoring them the way they would've if those messages had been presented in the format of non-fiction literature. To put it bluntly the main message of the game is how self delusion reinforces the very things it seeks to escape whether those be personal problems like loneliness or societal ones like the anxiety inducing political limbo of Revachol/the real world. Included in the delusions of a political nature Kurvitz wanted people to confront were many held by the bulk of the contemporary left. Sadly, judging by what I often see in this sub, the results of this novel approach at polemics has been mixed.
I have to admit it's disheartening to see how many fans of the game only engaged with that social and political criticism to the extent that it was leveled at their political enemies, especially when the "authorial intent" was to confront players who might delude themselves about the future implications, present realities and/or history of their own real life politics, whatever they may be. In some cases this ignorance is forgivable; it's easy to miss subtext in a game that's so text based that it has a habit of spelling things out for you and tbf many of the allusions to real life figures, events and ideas are subtle and without a solid grasp of 20th century European history and theoretical Marxism most of the satirical references will go over a typical player's head. What's not forgivable is how many people in this sub are in denial of or otherwise consciously rationalize the criticisms of their own side presented by the writers of DE. I'll get around to how centrists and right-libertarians are guilty of this in future posts but for right now I want to address "my comrades" because, frankly, some of you scare me with your naiveté, hyper-partisanship and blithe hand waving of corruption and needless violence.
Now there are two kinds of leftists I often see who want to view Evrart as a crypto-communist figure and despite being polar opposites in most respects they have two things in common: they're both childishly naive and they're both in denial about the realities of how vicious social democracy can be in practice. The first leftist is a social democrat who thinks that because Evrart is a machiavellian strongman figure that he must be an expy of Stalin and/or Mao (who in their minds are genuine representatives of communism) because "never, ever would a real social democrat do such things, after all we're unassuming trade unionists who want nothing more than to work things out democratically, through the existing system!" The second leftist is a communist who thinks that because Evrart is a machiavellian strongman figure that he must be an expy of Stalin and/or Mao (who in their minds are genuine representatives of communism) because "never, ever would a real social democrat do such things, after all they're unassuming trade unionists who want nothing more than to work things out democratically, through the existing system!"
The truth of course is that prejudices aside Evrart is a social democrat AND a tyrannical strongman. As for his plan to seize the harbor, while it's certainly threatening to Wild Pines' bottom line, the RCM's authority and the union's enemies in Martinaise, it does not in any way pose a genuine revolutionary threat to the capitalist system as a whole and, as weird as it may sound, is still reliant on working within the existing system. After all the union didn't seize the means of production in an armed rebellion against the capitalist state so much as Wild Pines legally handed over some of its corporate property to the union to avoid the bad PR of the merc tribunal which in the end was only tangentially related to the strike. By the end of HBD's investigation all that has changed for the (surviving) workers of Martinaise Harbour Terminal B is their employer. They went from being the unionized employees of the Wild Pines Group under which they had to smuggle drugs in secret to get by to becoming members of a de jure workers' co-operative under the Claires' control where they can now smuggle drugs more openly. That's it. Is that better for them? Maybe, probably, but even so they're still reliant on a global system based on commodity production and exchange and the selling of their labor power (and hardcore drugs) for money, they've just cut out a few middlemen so to speak. Once the strike is officially declared over La Puta Madre's henchmen, not the soldiers of the Coalition, are going to be the union's most immediate threat. Wild Pines itself probably isn't even that hurt by Evrart's plan as the value of what was lost in revenue and real estate can be mitigated by the amount the company will save from no longer having 2,000 + employees on its payroll every quarter.
Oh and to those pragmatists who think Evrart is just a well intentioned man willing to step up and get his hands dirty for the sake of his fellow workers because no one else would or as Call Me Mañana puts it "The old man is corrupt for our benefit" this next part is for you. We know from interviews that Evrart was partially inspired by the character of Frank Sobotka from the second season of the HBO hit TV series The Wire. That said Evrart is in many ways a sort of anti-Sobotka insofar as he's not just reluctantly working with mafiosos; he *is* a mafioso. If you haven't already seen The Wire you need to stop reading this and go watch it to not only understand my next point but because it's literally the best TV show ever made. For those who have seen The Wire I'm 100% certain you'll agree with me that neither of the two hypothetical leftists from earlier could seriously claim that Sobotka was a secret communist or anything other than a reformist labor leader even though he's guilty of most of the same things that supposedly make crypto-commies of the Claires. I also don't think anyone who's seen the show would strongly hate Frank for getting involved in those criminal dealings the way they would the Claires even if some might still think both are wrong for having done so. Most importantly I don't think anyone who's seen all of season two of The Wire and played Disco Elysium to completion would ever claim that the Claires cared more about the Martinaise dockers than the Sobotka family did the stevedores of Locust Point, Baltimore. So what explains the gulf between the two unionistas (besides murder)? Why was it less bad when Frank Sobotka engaged in labor racketeering than when Evrart and Edgar did it? It's simple really, Frank Sobotka demonstrated more authentic labor solidarity, internal conflict, selflessness and above all self awareness than the Claire brothers ever did.
So to summarize: the Claires are written as a counter to those players who have what Lenin called trade union consciousness (meaning social democrats, progressives and center-left, reform minded liberals) who think that the problems of capitalism can be solved simply by increasing the number of trade unions, by legally incorporating more worker co-ops, by expanding strike funds, etc., in a word, reformism. Additionally DE's writers, who're communists, want to knock reformists off their high horses so as to get them to stop lying to themselves and recognize that there is corruption, hypocrisy, violence and even a small presence of incipient fascism in many real life unions, both past and present, and that existing reformist movements, organizations, etc. are just as susceptible to being hijacked by populist demagogues as revolutionary ones are/have been and moreover that they're not always the politically correct, morally unimpeachable, nonviolent alternatives to revolution that they present themselves as. In the end class conflict and its resulting violence goes on whether anyone wants it to or not. It can be and often is a totally subconscious process driven by need at both the individual and group levels. That said the longer class conflict goes on without being consciously directed towards the abolishment of the socioeconomic system whose inherent contradictions bring it into being in the first place, the more chaotic it will become until the point where the mutual ruin of the competing classes is all but guaranteed as a result.
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2023.06.09 09:57 AutoModerator [Genkicourses.site] ✔️Dan Koe – Digital Economics Masters Degree ✔️ Full Course Download

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Phase 0) Digital Economics 101

The Digital Economics 101 module will open 1 week prior to the cohort start date.This is an onboarding module that will get you up to speed so we can get straight into the material.This will be required to finish before the start date.
  • Gain a deep understanding of all of the pieces in the digital economy.
  • Learn about the future of media and code — the front-end and backend of the internet — so you can focus your efforts.
  • Understand digital leverage, distribution, no-code tools, and digital assets so you can take part in the mental & financial wealth transfer.

Phase 1) Creating A Meaningful Niche

Every day I hear people going on and on about trying to find their niche.I also hear people talking about how they don’t know how to combine what they love talking about with what will sell.You already have the answer. You just don’t have the clarity.
  • Develop a long-term strategy to create your own niche — meaning you don’t have to worry about your “competition” playing status games.
  • Discover your life’s work, curiosities, and obsessions. I see too many people that are uncertain about this for years.
  • Cultivate and turn your vision, goals, and values into a brand that attracts an audience you love interacting with (and that will buy from you, and only you).

Phase 2) Content Strategy

There is one thing that separates those who make it in the digital economy and those who don’t.It’s the quality, articulation, and perceived originality of their content.The content you post has to make sense to the people you attract.Everyone has a different voice and tone that they resonate with. That they are congruent with and trust.It has to change their thought patterns or behavior — that’s what makes you memorable.That’s what separates you from the sea of people posting surface-level copy-cat style posts.Example and putting my money where my mouth is:
  • Become an expert-level speaker or writer on the topics you care about.
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  • Create posts, blogs, tweets, images, and videos that resonate with other’s on a deep level. People will actually ask you how you got so good at what you do.
  • Separate yourself from the ocean of B-tier creators that struggle to sell their products, services, andhave their ideas stick in the head of their audience.
  • Implement our Epistemic Research Method — which is just a fancy way of saying scientific research method… but it’s for researching your mind to craft brilliant content and product ideas.

Phase 3) Crafting Your Offer

Most people are sitting on a goldmine of skills, experience, and knowledge (that they can use to help people 1-2 steps behind them).That is what people pay for.Considering 95% of the market are beginners… if you are good at something, you can help them get to your level (no matter how “basic” you think the information is).Do you not watch basic content all day anyway? People don’t want new information, they want to be reminded of what works.
  • Use our Minimum Viable Offer strategy to start monetizing immediately (and have something to improve over time, rather than procrastinating until it’s perfect).
  • Have a strategy for reducing the time you spend working over time (as you build leverage and improve your offer).
  • Know how to create your own customers from the audience you are building, instead of “finding” the right customer for your offer.
  • Take the guesswork out of building coaching, consulting, or digital product offers.

Phase 4) Marketing Strategy

You aren’t making money because you aren’t promoting yourself or your offer.That is literally the only way to make money. Have something desirable and consistently put it in front of peoples’ faces.In Phase 4, I will show you how to systemize, automate, and be consistent with simple promotions.You will be able to make money without having the chance of forgetting to do it (or letting fear of failure get in the way).
  • Learn to sell on social media, in your writing, and across different platforms.
  • Have consistent sales coming in while focusing on your meaningful message (no need to sound salesy all the time).
  • Learn advanced automation strategies that you can implement at your own pace, especially once you validate your offer.

Bonus) The Creator Command Center

The Creator Command Center is a Notion template that houses all of the systems.This is how you will manage your brand, content, offer creation, marketing strategy, and systemized promotions for consistent sales.

Bonus) Live Product Build & Launch

In the first Digital Economics Cohort, I built out my course The 2 Hour Writer.I have videos showing how I build it with the strategies in phase 3 and 4.There is a bonus module that shows how I had an $85,000 launch that resulted in my first $100K month.I did this to prove the strategies inside Digital Economics work if you stick to the plan.And, this past Black Friday, I blew my that monthly high out of the water in 4 days.That’s the power of these strategies if you stay consistent with your life’s work.
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2023.06.09 09:43 summitmedical Top-Rated Rehabilitation Facility in Colorado Springs

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Welcome to the renowned Rehabilitation Center in Colorado Springs, a premier facility dedicated to restoring and enhancing the lives of individuals seeking recovery and wellness. Additionally, we offer a range of wellness programs to support long-term recovery and promote overall well-being. Choosing our Rehabilitation Center in Colorado Springs means entrusting your care to a facility that prioritizes your well-being and dedicates itself to helping you achieve lasting recovery. We are committed to supporting and guiding you every step of the way on your path to wellness. Contact us today! We can assist you or your loved one in achieving optimal health and reclaiming a fulfilling life.
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2023.06.09 09:33 solankehospital Best Gynaecology Department Doctor in Shegaon

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2023.06.09 09:15 DrkiranReddyCh Best Sports Medicine Doctor In Hyderabad

Kindle Clinics: Transforming Lives with Exceptional Orthopedic Care

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At Kindle Clinics, we firmly believe in putting our patients at the center of everything we do. Our compassionate team ensures that you receive personalized care, focusing on your unique needs and goals. We strive to provide a warm and welcoming environment where you feel comfortable discussing your concerns and receiving the highest level of orthopedic care.

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At Kindle Clinics, we understand that successful recovery extends beyond medical interventions. Therefore, we adopt a holistic approach to ensure comprehensive healing for our patients. Our team includes dedicated physiotherapists and rehabilitation specialists who work closely with you to design tailored rehabilitation programs that promote a swift and effective recovery.

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Choose Kindle Clinics for Unrivaled Orthopedic Care

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2023.06.09 09:08 kiranreddych Best Orthopedic Surgeon in Hyderabad - Dr. Kiran Reddy Chennuri

Orthopedic health issues can significantly impact one's quality of life, and finding the right specialist is crucial for effective treatment and recovery. In Hyderabad, one name that stands out among the rest is Dr. Kiran Reddy Chennuri, an esteemed orthopedic surgeon known for his exceptional skills, expertise, and patient-centered approach. With extensive experience in orthopedic surgery, Dr. Chennuri has gained a reputation as the Best Orthopedic Surgeon in Hyderabad.
Orthopedic surgery involves the diagnosis, treatment, and prevention of conditions affecting the musculoskeletal system. From fractures and joint replacements to sports injuries and chronic pain, orthopedic surgeons play a vital role in restoring mobility and improving the overall quality of life for their patients.
Overview of Orthopedic Surgery
Orthopedic surgery encompasses a wide range of procedures and treatments, each tailored to address specific conditions and injuries. From conservative approaches like physical therapy and medication management to surgical interventions, orthopedic surgeons evaluate the best course of action based on the patient's unique needs and circumstances.

Importance of Choosing the Best Orthopedic Surgeon

When it comes to orthopedic concerns, selecting the right surgeon can make all the difference. The best orthopedic surgeons combine exceptional medical expertise with a patient-centric approach, ensuring personalized care, successful outcomes, and overall patient satisfaction.

Introducing Dr. Kiran Reddy Chennuri

Dr. Kiran Reddy Chennuri is a highly regarded orthopedic surgeon based in Hyderabad, India. With a passion for providing comprehensive and compassionate care, Dr. Chennuri has established himself as one of the leading specialists in the field. He is renowned for his commitment to patient well-being and his unwavering dedication to delivering the best possible outcomes.

Specializations: Knee Replacement and Sports Medicine

As a specialist in orthopedic surgery, Dr. Chennuri has focused his expertise on two key areas: Knee Replacement Surgery and sports medicine. These areas require a delicate balance of surgical proficiency, technical skills, and a deep understanding of the unique challenges patients face. Chennuri's specialized knowledge in these domains has earned him recognition as the best knee replacement surgeon and sports medicine doctor in Hyderabad.

Best Sports Medicine Doctor in Hyderabad - Dr Kiran Reddy Chennuri

Dr. Kiran Reddy Chennuri is recognized as one of the Top Sports Medicine Doctors in Hyderabad. He is highly regarded for his expertise in the field of sports medicine and his commitment to providing exceptional care to athletes and individuals with sports-related injuries. Dr. Kiran Reddy Chennuri has extensive experience in diagnosing and treating a wide range of sports injuries, including ligament sprains, muscle strains, fractures, and joint dislocations.
Dr. Kiran Reddy Chennuri is known for his comprehensive approach to sports medicine, combining advanced medical knowledge with a deep understanding of sports and physical activity. He believes in personalized treatment plans tailored to each patient's specific needs and goals, aiming to help them recover and return to their active lifestyles as quickly and safely as possible.
With his strong educational background and years of practical experience, Dr. Kiran Reddy Chennuri stays up-to-date with the latest advancements in sports medicine. He utilizes cutting-edge diagnostic techniques and evidence-based treatment modalities to ensure the best possible outcomes for his patients.
Beyond his clinical practice, Dr. Kiran Reddy Chennuri actively contributes to the field of sports medicine through research, publications, and participation in conferences. He is dedicated to advancing the knowledge and understanding of sports-related injuries, and he constantly strives to improve his skills and expertise.

Best Doctor for Knee Pain - Dr. Kiran Reddy Chennuri

Knee pain can significantly impact one's quality of life, hindering mobility and causing discomfort. When faced with knee pain, it is crucial to seek the expertise of a specialist who can provide effective treatment and relief. If you are searching for the Best Doctor for Knee Pain in Hyderabad, look no further than Dr. Kiran Reddy Chennuri. With his exceptional qualifications, specialized knowledge, and commitment to patient care, he is widely recognized as a leading authority in the field of knee pain treatment.
Knee pain is a prevalent condition that affects people of all ages, ranging from athletes to the elderly. It can be caused by various factors, such as injuries, arthritis, overuse, or underlying medical conditions. When knee pain becomes persistent or severe, it is essential to consult a qualified medical professional who specializes in diagnosing and treating knee pain.

Understanding Knee Pain

To better comprehend knee pain and its significance, it is important to explore its causes and common conditions associated with it.
Causes of Knee Pain
Knee pain can stem from several causes, including:

Common Knee Pain Conditions

Some common conditions associated with knee pain include:
  1. Patellofemoral Pain Syndrome (PFPS): A condition characterized by pain in the front of the knee, often caused by overuse or misalignment of the kneecap.
  2. Runner's Knee (Patellar Tendinitis): A condition that affects athletes and individuals engaged in repetitive knee movements, causing pain around the kneecap.
  3. Osteoarthritis: The most common form of arthritis that affects the knee joint, causing stiffness, swelling, and pain.
  4. Ligament Tears: Injuries to the ligaments in the knee, such as ACL or MCL tears, which can occur during sports or accidents.
  5. Meniscus Tears: Tears in the meniscus, often resulting from sudden twisting or direct impact to the knee.

Conclusion

In conclusion, Dr. Kiran Reddy Chennuri is highly regarded as one of the best orthopedic doctors in Hyderabad. With his expertise, experience, and patient-centered approach, he has earned a strong reputation in the field of orthopedics. Dr. Kiran Reddy Chennuri's exceptional diagnostic abilities and proficiency in orthopedic surgery have enabled him to successfully treat numerous patients with various bone and joint disorders, sports injuries, fractures, and musculoskeletal conditions.
Location Details
Opposite KS Bakers, Plot No.1 & 2, Old Mumbai Hwy, Indira Nagar, Gachibowli, Telangana 500032
Consult Now
+91 9000022004
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2023.06.09 08:57 AutoModerator [Genkicourses.site] ✔️Dan Koe – Digital Economics Masters Degree ✔️ Full Course Download

[Genkicourses.site] ✔️Dan Koe – Digital Economics Masters Degree ✔️ Full Course Download
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Courses proof (screenshots for example, or 1 free sample video from the course) are available upon demand, simply Contact us here

Download Full Course – Instant Delivery

What You Get

Phase 0) Digital Economics 101

The Digital Economics 101 module will open 1 week prior to the cohort start date.This is an onboarding module that will get you up to speed so we can get straight into the material.This will be required to finish before the start date.
  • Gain a deep understanding of all of the pieces in the digital economy.
  • Learn about the future of media and code — the front-end and backend of the internet — so you can focus your efforts.
  • Understand digital leverage, distribution, no-code tools, and digital assets so you can take part in the mental & financial wealth transfer.

Phase 1) Creating A Meaningful Niche

Every day I hear people going on and on about trying to find their niche.I also hear people talking about how they don’t know how to combine what they love talking about with what will sell.You already have the answer. You just don’t have the clarity.
  • Develop a long-term strategy to create your own niche — meaning you don’t have to worry about your “competition” playing status games.
  • Discover your life’s work, curiosities, and obsessions. I see too many people that are uncertain about this for years.
  • Cultivate and turn your vision, goals, and values into a brand that attracts an audience you love interacting with (and that will buy from you, and only you).

Phase 2) Content Strategy

There is one thing that separates those who make it in the digital economy and those who don’t.It’s the quality, articulation, and perceived originality of their content.The content you post has to make sense to the people you attract.Everyone has a different voice and tone that they resonate with. That they are congruent with and trust.It has to change their thought patterns or behavior — that’s what makes you memorable.That’s what separates you from the sea of people posting surface-level copy-cat style posts.Example and putting my money where my mouth is:
  • Become an expert-level speaker or writer on the topics you care about.
  • Never run out of content ideas for your posts or promotions (without using content templates — that’s how you stay a commodity).
  • Create posts, blogs, tweets, images, and videos that resonate with other’s on a deep level. People will actually ask you how you got so good at what you do.
  • Separate yourself from the ocean of B-tier creators that struggle to sell their products, services, andhave their ideas stick in the head of their audience.
  • Implement our Epistemic Research Method — which is just a fancy way of saying scientific research method… but it’s for researching your mind to craft brilliant content and product ideas.

Phase 3) Crafting Your Offer

Most people are sitting on a goldmine of skills, experience, and knowledge (that they can use to help people 1-2 steps behind them).That is what people pay for.Considering 95% of the market are beginners… if you are good at something, you can help them get to your level (no matter how “basic” you think the information is).Do you not watch basic content all day anyway? People don’t want new information, they want to be reminded of what works.
  • Use our Minimum Viable Offer strategy to start monetizing immediately (and have something to improve over time, rather than procrastinating until it’s perfect).
  • Have a strategy for reducing the time you spend working over time (as you build leverage and improve your offer).
  • Know how to create your own customers from the audience you are building, instead of “finding” the right customer for your offer.
  • Take the guesswork out of building coaching, consulting, or digital product offers.

Phase 4) Marketing Strategy

You aren’t making money because you aren’t promoting yourself or your offer.That is literally the only way to make money. Have something desirable and consistently put it in front of peoples’ faces.In Phase 4, I will show you how to systemize, automate, and be consistent with simple promotions.You will be able to make money without having the chance of forgetting to do it (or letting fear of failure get in the way).
  • Learn to sell on social media, in your writing, and across different platforms.
  • Have consistent sales coming in while focusing on your meaningful message (no need to sound salesy all the time).
  • Learn advanced automation strategies that you can implement at your own pace, especially once you validate your offer.

Bonus) The Creator Command Center

The Creator Command Center is a Notion template that houses all of the systems.This is how you will manage your brand, content, offer creation, marketing strategy, and systemized promotions for consistent sales.

Bonus) Live Product Build & Launch

In the first Digital Economics Cohort, I built out my course The 2 Hour Writer.I have videos showing how I build it with the strategies in phase 3 and 4.There is a bonus module that shows how I had an $85,000 launch that resulted in my first $100K month.I did this to prove the strategies inside Digital Economics work if you stick to the plan.And, this past Black Friday, I blew my that monthly high out of the water in 4 days.That’s the power of these strategies if you stay consistent with your life’s work.
submitted by AutoModerator to GenkiCourses_Cheapest [link] [comments]


2023.06.09 08:37 shaikhiba lady skin specialist in kurnool

Clear Skin Hair & Laser Center in Kurnool is a healthcare facility that offers a range of cosmetic and medical services to help improve the appearance and health of patients' skin, hair, and body. They use advanced technologies and techniques, including laser therapy, to provide treatments that are safe, effective, and personalized to meet each patient's individual needs and goals. The center has a team of experienced and qualified professionals who work together to provide comprehensive and compassionate care to their patients. They are committed to helping their patients achieve clear, healthy, and beautiful skin, hair, and body.
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2023.06.09 07:58 -PrecYse- [WTS] Benchmade Mini Crooked River , S30V / wood

For sale (no trades please)
Benchmade Mini Crooked River , 3.4inch S30V blade, 4.5inch total length, stabilized wood/aluminum
https://imgur.com/a/Kd3fuD5
Purchased a bit less than a year ago (original owner) , came off center out the box, didnt affect its functionality so never bothered to get it sent in or swapped out. Also never carried ,used, sharpened. Put the clip on the opposite side thinking id end up using it, never did (im a lefty).
See video for action, drops shut, smooth and swift opening, off center but doesnt affect action at all, just annoying to look at but can probably be fixed if youve had any dealings with off centered knives.
Take it off my hands, letting go of a bunch of knives i dont use
SV: 200 Paypal G&S only SOLD
Ships via UPS the next business day, CONUS only
Thank you for viewing, take care!
submitted by -PrecYse- to Knife_Swap [link] [comments]


2023.06.09 07:57 AutoModerator [Genkicourses.site] ✔️Dan Koe – Digital Economics Masters Degree ✔️ Full Course Download

[Genkicourses.site] ✔️Dan Koe – Digital Economics Masters Degree ✔️ Full Course Download
➡️https://www.genkicourses.site/product/dan-koe-digital-economics-masters-degree/⬅️
Get the course here: [Genkicourses.site] ✔️Dan Koe – Digital Economics Masters Degree ✔️ Full Course Download
https://preview.redd.it/ab8hk3ydax4b1.jpg?width=1000&format=pjpg&auto=webp&s=d1e3bf79694f9d830d76c55e609ff2f25ce48ada

Courses proof (screenshots for example, or 1 free sample video from the course) are available upon demand, simply Contact us here

Download Full Course – Instant Delivery

What You Get

Phase 0) Digital Economics 101

The Digital Economics 101 module will open 1 week prior to the cohort start date.This is an onboarding module that will get you up to speed so we can get straight into the material.This will be required to finish before the start date.
  • Gain a deep understanding of all of the pieces in the digital economy.
  • Learn about the future of media and code — the front-end and backend of the internet — so you can focus your efforts.
  • Understand digital leverage, distribution, no-code tools, and digital assets so you can take part in the mental & financial wealth transfer.

Phase 1) Creating A Meaningful Niche

Every day I hear people going on and on about trying to find their niche.I also hear people talking about how they don’t know how to combine what they love talking about with what will sell.You already have the answer. You just don’t have the clarity.
  • Develop a long-term strategy to create your own niche — meaning you don’t have to worry about your “competition” playing status games.
  • Discover your life’s work, curiosities, and obsessions. I see too many people that are uncertain about this for years.
  • Cultivate and turn your vision, goals, and values into a brand that attracts an audience you love interacting with (and that will buy from you, and only you).

Phase 2) Content Strategy

There is one thing that separates those who make it in the digital economy and those who don’t.It’s the quality, articulation, and perceived originality of their content.The content you post has to make sense to the people you attract.Everyone has a different voice and tone that they resonate with. That they are congruent with and trust.It has to change their thought patterns or behavior — that’s what makes you memorable.That’s what separates you from the sea of people posting surface-level copy-cat style posts.Example and putting my money where my mouth is:
  • Become an expert-level speaker or writer on the topics you care about.
  • Never run out of content ideas for your posts or promotions (without using content templates — that’s how you stay a commodity).
  • Create posts, blogs, tweets, images, and videos that resonate with other’s on a deep level. People will actually ask you how you got so good at what you do.
  • Separate yourself from the ocean of B-tier creators that struggle to sell their products, services, andhave their ideas stick in the head of their audience.
  • Implement our Epistemic Research Method — which is just a fancy way of saying scientific research method… but it’s for researching your mind to craft brilliant content and product ideas.

Phase 3) Crafting Your Offer

Most people are sitting on a goldmine of skills, experience, and knowledge (that they can use to help people 1-2 steps behind them).That is what people pay for.Considering 95% of the market are beginners… if you are good at something, you can help them get to your level (no matter how “basic” you think the information is).Do you not watch basic content all day anyway? People don’t want new information, they want to be reminded of what works.
  • Use our Minimum Viable Offer strategy to start monetizing immediately (and have something to improve over time, rather than procrastinating until it’s perfect).
  • Have a strategy for reducing the time you spend working over time (as you build leverage and improve your offer).
  • Know how to create your own customers from the audience you are building, instead of “finding” the right customer for your offer.
  • Take the guesswork out of building coaching, consulting, or digital product offers.

Phase 4) Marketing Strategy

You aren’t making money because you aren’t promoting yourself or your offer.That is literally the only way to make money. Have something desirable and consistently put it in front of peoples’ faces.In Phase 4, I will show you how to systemize, automate, and be consistent with simple promotions.You will be able to make money without having the chance of forgetting to do it (or letting fear of failure get in the way).
  • Learn to sell on social media, in your writing, and across different platforms.
  • Have consistent sales coming in while focusing on your meaningful message (no need to sound salesy all the time).
  • Learn advanced automation strategies that you can implement at your own pace, especially once you validate your offer.

Bonus) The Creator Command Center

The Creator Command Center is a Notion template that houses all of the systems.This is how you will manage your brand, content, offer creation, marketing strategy, and systemized promotions for consistent sales.

Bonus) Live Product Build & Launch

In the first Digital Economics Cohort, I built out my course The 2 Hour Writer.I have videos showing how I build it with the strategies in phase 3 and 4.There is a bonus module that shows how I had an $85,000 launch that resulted in my first $100K month.I did this to prove the strategies inside Digital Economics work if you stick to the plan.And, this past Black Friday, I blew my that monthly high out of the water in 4 days.That’s the power of these strategies if you stay consistent with your life’s work.
submitted by AutoModerator to GenkiCourses_Cheapest [link] [comments]


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2023.06.09 07:37 highlandcare Top Rehabilitation Centers in Jamaica and Queens, NY Highland Care Center

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2023.06.09 07:35 Zagaroth [No Need For A Core?] - CH 092: The Enclaves

Cover Art <<Previous Start Next >>
Each faction was going to need an encampment, and Mordecai decided to start there. He placed each one on opposite sides of the cavern at its widest point, approximately midway between the entrance and exit. He’d sculpted the cavern to have interesting terrain, so the widest point was a touch off of the center.
He was only going to do part of the work for the encampments, leaving the customization to the laganthros who would be playing the parts. For the moment he started by clearing out a circle of terrain for each side, with half of the circle being carved out of the wall behind them and the other half being out front. The sub-caverns created this way were 20 feet tall, giving them plenty of room to build as they liked.
Now he created small gardens for a new set of mushrooms, special breeds for use as items. The first set of cultivated fungi had their use based off of their normal appearance:
Broad-capped mushrooms were reinforced and designed to be readily broken off to be used as shields. A variant of Morels whose craggy nooks could be used as shelving, trumpet-shaped mushrooms that could be used for a limited time to greatly amplify shouted words, bell-shaped mushrooms that would actually chime when a living creature approached, squat trunk mushrooms that could be grown small or large to act as stools or tables, plus some cupped shaped ones that could easily become actual cups or bowls. He would create more as requested, he couldn’t think of everything himself that others might need, but the goal was to make it so that the two factions had almost everything they needed to equip themselves and to build.
Mordecai ventured further afield with his next set of mushrooms for gardening however. The living crystal had given him an idea when he’d considered the problem of making normally metal items. The mushrooms in this field grew in a variety of shapes but were very heavily infused with living crystals and all grew in spreading patterns. The outer heads are where the crystal would concentrate the most, eventually causing them to crack off on the outermost edge. The resulting material could be knapped much like flint or obsidian to a razor-sharp edge, but over the next couple of days would harden to a toughness more like that of nephrite, i.e. true jade. Jadeite was the more common stone called jade because of its similar appearance, but it was not quite as tough or as hard as nephrite.
It wouldn’t cover everything metal could do, but would be more than sufficient for making weapons if napped, or for anything from art to tools if shaped only after it was fully hardened. Empires could be founded without advanced metallurgy if they had access to even normal nephrite, let alone what could be done with this crystal.
He also altered some mushrooms to sit more ‘in between’. With a more lightweight infusion of crystal for structural support, it was not hard to create fungi whose various parts could be used as raw construction material, whether akin to ropes or materials that could act like wood, if a touch spongier.
Now that he had raw materials down, it was time to call in his troops. Most of them were simply going to be the strongest of the laganthros in their respective specialties, though he did have a couple of additions to make.
The right side encampment was the easiest to assign, calling up some ‘light cavalry’ mounted on polecats, and some aerial cavalry in the form of mages mounted on dracobits, with scouting/infantry support from rangers bonded to caracals.
The left side he gave to ‘heavy infantry’, though he had to make their mounts first. The Riverbridge gifts and trades came in handy here as there had been some farm animals included, and before long he had his porcini boars. And he had them live up to the pun too, growing the squat mushrooms from their thick hide and fur, forming a natural saddle shape as well as extra protection for both the boar and the rider. It was admittedly a more outlandish hybridization than, say, an owl bear, but at least he’d be able to adjust and fix any issues that cropped up.
For support, he gave them various rabbats as ‘falconry’, providing both scouts and an aerial force, and sharpshooters of both archery and gun varieties. The guns were one of the few things that absolutely had to be made out of metal, he couldn’t find a way to reinforce any form of crystal to withstand the shock pressure of the firing chamber. Maybe as a deeper dungeon they could create a heavily enchanted crystal if they wanted to, but it didn’t seem worth the effort.
And the final creation for this level he made as support for both sides, though purely defensively. To take the place of guard dogs, he altered and enlarged some badgers, creating two colonies of Giant Badgers. He only had to alter their base personalities a little, most badgers were quite capable of being social and of being aggressively defensive, he just had to tighten up their pack bonding and ability to work in groups. He also made sure that they were completely immune to all fungal spores and toxins to be found in this dungeon, which also gave them a general boost against toxins and diseases. Dungeon creatures may not have to eat, but it feels natural for them to do so and he wanted to fit them in here with the ability to eat any mushrooms.
Once he was certain that everything was settled well enough, he met with the leaders of his two factions in the safe-space camping spot at the level’s entrance.
“So, what do you think of your enclaves?” Was what he started with, and that led to a couple of hours of discussions, questions, and answers. When all that was settled, Mordecai moved on to making sure everyone was on the same page concerning rules.
“I want this to be a bit more free form than what we’ve done before. You don’t absolutely have to fight any dungeon challengers, but you do have to play the part of a warring party on high alert and be highly suspicious of intruders.” He grinned at them. “If you need to, you can take some acting lessons from your cousins on the third floor. Might make for a good part of that training exchange I set up previously. But you don’t have to let them pass by either. You can deny them passage, you can demand tribute, you can form alliances, or otherwise act how you like. This should all be very dynamic. The only rule I make absolute for you and yours is that this zone right here is a safe space for them. Mind, I am only being so nice here, the ‘wildlife’ won’t be burdened by that obligation, but generally won’t have a reason to attack this location anyway.”
“And when there aren’t any challengers?” Asked one of the troop captains.
“Mostly up to you for the details, I just want at least some of you to be training against each other most days. You’ve been very diligent in forming your own schedules before, I don’t see any reason to change that now. But I’ll let you know if I spot anything I think can be improved on. Similarly, I expect you to let me know if there is anything I can improve. I think I’ve balanced your forces, the forest is heavy enough to keep the mages and dracobits from dominating the battlefield, but if your battle practice shows that I need to change that balance, I want you to tell me.”
The rabbit folk talked with each other for a bit, then when they had reached a consensus turned back to him. “We’re satisfied with this new role my lord. There are a few who have decided they aren’t quite comfortable here after all, but we can find some other recruits to fill their spots so you don’t have to worry about it.”
“Excellent. Oh, one final thing, as a default no one is to support the boss fight.” Which was a change from most of the previous floors. “The exception is if your enclave is assaulted. If that happens and you survive, then you should rally at the final chamber for the floor and support the boss or bosses.”
“Oh, what do you have planned for our bosses?” Came the excited query.
Mordecai smiled. “Well, I’ll show you before too long. For now, you should know that they are not going to start out the brightest and could be hazardous if you get too close, so be very careful if you do end up supporting them. And their names will be Sarcomaag and Klastoria.”
What is up with those names?” Kazue’s voice asked in his head.
I’m just having some fun messing around with relevant words.” he replied before focusing back on the faction leaders. “I think they’ll be an interesting new challenge for people who get this far.”
.
While the two dungeon cores had fun finally building out their fifth level, the rest of the world continued about its business. Their wife was finishing her preparations to come back home and bring Kazue’s father with her, including a quick side shopping trip that she was very careful to not let them in on, which was much easier to do while they were distracted.
Traveling south from the capital city was a merchant caravan with a champion as part of its escort. They moved slowly of course, but by the time they had to start setting up camp the last spires of the city’s central keep were lost over the horizon behind them.
News of their existence was beginning to spread in earnest now, and some of that news even managed to get their names right. The oddness of a dual-core was going to stir curiosity at the least, but it was Mordecai’s name that would serve as the biggest catalyst for making their life more interesting, in differing measures of good and ill.
<<Previous Start Next >>
My Discord if you would like to talk about the book or see what else I am up to.
My Patreon if you want to support me directly.
Also to be found on Royal Road.
$3 Patreon: Early chapters, lore excerpts $5 Patreon: Short Stories $10 Patreon: New stories not published anywhere else (Until after I finish this story at least)
submitted by Zagaroth to redditserials [link] [comments]


2023.06.09 06:57 AutoModerator [Genkicourses.site] ✔️Dan Koe – Digital Economics Masters Degree ✔️ Full Course Download

[Genkicourses.site] ✔️Dan Koe – Digital Economics Masters Degree ✔️ Full Course Download
➡️https://www.genkicourses.site/product/dan-koe-digital-economics-masters-degree/⬅️
Get the course here: [Genkicourses.site] ✔️Dan Koe – Digital Economics Masters Degree ✔️ Full Course Download
https://preview.redd.it/ab8hk3ydax4b1.jpg?width=1000&format=pjpg&auto=webp&s=d1e3bf79694f9d830d76c55e609ff2f25ce48ada

Courses proof (screenshots for example, or 1 free sample video from the course) are available upon demand, simply Contact us here

Download Full Course – Instant Delivery

What You Get

Phase 0) Digital Economics 101

The Digital Economics 101 module will open 1 week prior to the cohort start date.This is an onboarding module that will get you up to speed so we can get straight into the material.This will be required to finish before the start date.
  • Gain a deep understanding of all of the pieces in the digital economy.
  • Learn about the future of media and code — the front-end and backend of the internet — so you can focus your efforts.
  • Understand digital leverage, distribution, no-code tools, and digital assets so you can take part in the mental & financial wealth transfer.

Phase 1) Creating A Meaningful Niche

Every day I hear people going on and on about trying to find their niche.I also hear people talking about how they don’t know how to combine what they love talking about with what will sell.You already have the answer. You just don’t have the clarity.
  • Develop a long-term strategy to create your own niche — meaning you don’t have to worry about your “competition” playing status games.
  • Discover your life’s work, curiosities, and obsessions. I see too many people that are uncertain about this for years.
  • Cultivate and turn your vision, goals, and values into a brand that attracts an audience you love interacting with (and that will buy from you, and only you).

Phase 2) Content Strategy

There is one thing that separates those who make it in the digital economy and those who don’t.It’s the quality, articulation, and perceived originality of their content.The content you post has to make sense to the people you attract.Everyone has a different voice and tone that they resonate with. That they are congruent with and trust.It has to change their thought patterns or behavior — that’s what makes you memorable.That’s what separates you from the sea of people posting surface-level copy-cat style posts.Example and putting my money where my mouth is:
  • Become an expert-level speaker or writer on the topics you care about.
  • Never run out of content ideas for your posts or promotions (without using content templates — that’s how you stay a commodity).
  • Create posts, blogs, tweets, images, and videos that resonate with other’s on a deep level. People will actually ask you how you got so good at what you do.
  • Separate yourself from the ocean of B-tier creators that struggle to sell their products, services, andhave their ideas stick in the head of their audience.
  • Implement our Epistemic Research Method — which is just a fancy way of saying scientific research method… but it’s for researching your mind to craft brilliant content and product ideas.

Phase 3) Crafting Your Offer

Most people are sitting on a goldmine of skills, experience, and knowledge (that they can use to help people 1-2 steps behind them).That is what people pay for.Considering 95% of the market are beginners… if you are good at something, you can help them get to your level (no matter how “basic” you think the information is).Do you not watch basic content all day anyway? People don’t want new information, they want to be reminded of what works.
  • Use our Minimum Viable Offer strategy to start monetizing immediately (and have something to improve over time, rather than procrastinating until it’s perfect).
  • Have a strategy for reducing the time you spend working over time (as you build leverage and improve your offer).
  • Know how to create your own customers from the audience you are building, instead of “finding” the right customer for your offer.
  • Take the guesswork out of building coaching, consulting, or digital product offers.

Phase 4) Marketing Strategy

You aren’t making money because you aren’t promoting yourself or your offer.That is literally the only way to make money. Have something desirable and consistently put it in front of peoples’ faces.In Phase 4, I will show you how to systemize, automate, and be consistent with simple promotions.You will be able to make money without having the chance of forgetting to do it (or letting fear of failure get in the way).
  • Learn to sell on social media, in your writing, and across different platforms.
  • Have consistent sales coming in while focusing on your meaningful message (no need to sound salesy all the time).
  • Learn advanced automation strategies that you can implement at your own pace, especially once you validate your offer.

Bonus) The Creator Command Center

The Creator Command Center is a Notion template that houses all of the systems.This is how you will manage your brand, content, offer creation, marketing strategy, and systemized promotions for consistent sales.

Bonus) Live Product Build & Launch

In the first Digital Economics Cohort, I built out my course The 2 Hour Writer.I have videos showing how I build it with the strategies in phase 3 and 4.There is a bonus module that shows how I had an $85,000 launch that resulted in my first $100K month.I did this to prove the strategies inside Digital Economics work if you stick to the plan.And, this past Black Friday, I blew my that monthly high out of the water in 4 days.That’s the power of these strategies if you stay consistent with your life’s work.
submitted by AutoModerator to GenkiCourses_Cheapest [link] [comments]


2023.06.09 06:31 manjirinadkarni_ 7 Signs Your Diet Is Harming You Instead Of Helping You

A healthy diet is crucial to your overall health and not just for weight loss. In my Ayurveda & Holistic Nutrition practice in Sarnia, I see many clients experimenting with multitudes of diets - Keto, Vegan, Paleo in order to lose weight or get healthy.
But often the crash dieting, yo-yo dieting or eating inaccurately (without considering your bodies requirements) leads to a lot of nutrient deprivation, lowered metabolism, muscle moss, fatigue, water retention and dehydration etc.
Food is the medicine and when used wisely can really support your body.
According to Ayurveda, Ahara or the food that you eat is one of the three important pillars on which your health rests. In simple words it means that your food is the very foundation of your health, how harmonious your body systems work together and how happy you are can also be determined through food.
A simple example of disharmony in the body can be understood by the food allergies and food sensitivities we see today. 8 out of 10 clients that see me, suffer from various food allergies and sensitivities to gluten, dairy, wheat, corn, soy, etc and this shows that their body is out of balance and harmony.

Our life revolves as well as evolves according to food that we eat.
Food is essential to our life and since humans can’t make our own food in our body, like plants, we have to eat food to provide us with energy. The food you eat makes each and every cell of your body and also affects your mind. Thus, nutritionally deficient foods will create a body that is weak vs nutritionally dense foods will support your body growth and create a body that is strong and resilient against aging and diseases. The food that you eat impacts your thoughts, behaviors, emotions and mood by influencing your mind - thus the food that you eat can make you calm, centered and balanced or anxious, irritable and depressed.

So how do you understand whether your diet/ nutritional plan is working for you or not?
You are not at a healthy weight
If you are struggling with gaining/ losing weight and following a diet/ nutritional plan without any results, this is the biggest indicator or your diet is failing you. Often people fall prey to trendy diets like keto, paleo, vegan or green smoothie diet. While these diets can actually work for you if they are custom tailored by using Ayurvedic principles by an experienced Ayurvedic doctor, following these without understanding your own body can create issues like muscle loss, loss of nutrients or excess fat gain.
Physical and mental fatigue
The food you eat is responsible for providing you with both physical as well as mental energy you require for daily activities. So if you are experiencing body and/or mental fatigue it could be a sign that your diet is deficient in essential nutrients that support your body. Often a restrictive diets aggravate Vata dosha in the long term and can significantly lower your energy levels.
You struggle with focus and concentrationOften food allergies and sensitivities, excess yeast growth aka Candida or a diet deficient in nutrients especially B vitamins can cause you to lack the focus and concentration required in day to day life. Artificial sweeteners like aspartame, food additives like food dyes, flavours and preservatives can contribute to hyperactivity and other symptoms of ADHD which can lower your focus and concentration.
Your skin lacks the lustre and toneYour skin is one of the biggest reflectors of health. If you are struggling with constant breakouts, acne, lacklustre skin that is wrinkly or hyper pigmented, the reason could be a faulty diet.Often poor diets will also make you lose the tone of your muscles as well as skin and cause skin to sag easily.
Your hair is dry, brittle or greying prematurelyHealthy, shiny lustrous hair often has more to do with a good diet, than the use of hair care products. And if you are finding your hair to be dry, brittle almost like the witches broom or prematurely grey, the reason is your diet is failing to provide the essential nutrients like Calcium, Phosphorus as well as collagen required for healthy hair.
You are struggling with digestive issues bloated and gassyConstant bloating and gas indicates an inability to digest the foods you are eating. If you follow a fad diet, which could often be full of the foods that you are sensitive to eg- excess dairy consumption in ketogenic diets or excess reliance on wheat gluten in vegan diet could result in signs of digestive distress like diarrhea, constipation, stomach cramps, undigested food in stool
You get sick easily
Are you constantly sick? Suffering from bouts of cold, flu, and recurrent infections? Well a poor diet often lowers your immunity making you prone to catching every cold and flu bug out there. If you have been sick more than 2-3 times a year for over 2 years it's time to get a reality check and sit with an Ayurvedic doctor to discuss what is causing your recurrent health issues.

Your body and mind are made from what you eat, so don't be fast, easy, cheap or fake.
This is something to be aware of, as in our fast paced life today, fast foods that are cheaper than fresh foods are on the rise. We eat quickly, foods that are prepared instantly and we find relief in filling the stomach and senses rather than nourishing and energizing the body. Protein shakes are taken as ‘fillers’, granola bars have replaced a well planned lunch and nutrition has become more of a means of calorie counting than actually nourishing our bodies. Often this is what can disconnect you from your body, mind and eventually from your health. So make a conscious choice every time you put something in your mouth or plan a specific diet.
submitted by manjirinadkarni_ to Ayurveda [link] [comments]


2023.06.09 05:21 btarb24 How to repair an EVGA x15 scroll wheel

How to repair an EVGA x15 scroll wheel
The x15 seems notorious for the scroll wheel failing and sometimes scrolling in the wrong direction. Some suggest turning it upside down and rolling the wheel on your desk. This may work temporarily, but the real fix is cleaning the contacts of the scroll wheel sensor (aka rotary encoder). I had two bad x15s and the cleaning repair worked perfectly on both.
Total time: ~ 20 minutes
Materials: tiny screw driver, sharp razor blade, q-tip, rubbing alcohol

  1. use a tiny flat screwdriver to remove the 3 mouse feet. I started with an inner side of each pad since those get the least amount of catch probability on the mouse pad when you're done.
  2. remove the 5 screws
  3. the top part of the mouse simply lifts off and does not have any 'snaps' to release on the edges - be careful there's a ribbon cable, but there's plenty of slack that you can just lay the top shell down and keep working without disconnecting it
  4. carefully unplug the mouse wheel sensor
  5. The wheel is simply held in via detents and friction. twist a flat screwdriver on the non-sensor side of the wheel and you'll release the small detent. The sensor side is held in via the wheel's axle snapping into the chassis - just grasp the wheel and lift up on it firmly - be sure you disconnected the wire from the board in step 4 first.
  6. now take the razor blade and slice off the 4 plastic rivet-like nubs on the back of the sensor. remember, cut toward your chum, not your thumb!
  7. now the back plate just pops off (reassembly - note the tab is clockwise of side with the wires. Also note the center hole of the plate is not flush. The hole should bump out toward the external side of the sensor)
  8. use your flat screwdriver to gently pop off the next layer, which is a little spring panel that gives you the tactile feel when you spin the wheel. (reassembly - note the pointy end is opposite the wires and the tip is bent downward toward the plastic wheel)
  9. next is the plastic detent wheel. careful - the bottom side of the wheel has very small metal prongs. (reassembly - the metal bits go downward and the detenty side is upward)
  10. ok, now you are left with just the housing. You'll see a metal plate at the bottom of it... and it'll be covered in black oily debris. Use your alcohol & q-tip to clean it well.
  11. reassemble in reverse. The two metal plates should slip on whats left of the studs. careful not to misalign them and then squeeze really hard to force it as that will probably smoosh the tiny plastic studs.
  12. use something to temporarily hold the pieces together.. i used small alligator clips, you could also have a buddy gently squeeze with needlenose pliers.
  13. use a soldering iron to melt some plastic. I used the tip of a zip tie, but any plastic your iron will melt should work. Get a small amount on the tip of your iron, then press it down onto where each of the 4 studs are. Work it around a good bit to ensure the new plastic melted to the old plastic studs.
  14. If you got too much plastic or too sloppily and it no longer fits into it's little house then just manipulate it with your iron, or use something like a fingernail file to remove some excess material until it fits again.

ALTERNATIVE - you can just replace the sensor entirely rather than taking it apart and cleaning it. They're around $5. The original brand was TTC. They come in various millimeter sizes and i'm not sure which one is correct, perhaps the yellow/orange center hole specifies the size?

start on inside edge. avoid using your fingertips - be sure to thoroughly wash hands if you want to reuse them and plan on touching the adhesive.

unplug the wire before removing the wheel

slice the 4 plastic circles off flush with the metal with a razor blade

lift off the back plate then gently lift off detent spring

note all the grime on the contacts. Clean it well.

one more pic just to show detent wheel for those that are curious

squeaky clean. so much dirt for such a little thing.

use something to hold the backing plate firmly in place before melting the plastic.

this one needed a small bit of filing to fit back into the mouse
submitted by btarb24 to EVGA [link] [comments]


2023.06.09 04:53 HowNowBrownCow82 Thoughts of this stain job? Any way to correct?

Thoughts of this stain job? Any way to correct?
Homeowner here, we’re going through a huge $200k+ insurance claim that resulted in new hardwoods throughout the house. There are several spots that the stain is dark…this is likely due to poor sanding, right? The photos above are the 3 worst spots. Other spots are near edges of the room.
What’s your professional opinion? Should we ask them to sand & restain? Anything to correct this without a full restain?
submitted by HowNowBrownCow82 to HardWoodFloors [link] [comments]


2023.06.09 04:40 Emotional-Disaster45 FTM positive birth story - unmedicated, birth center, midwife

Went into labor 40w2d. FTM.
I woke up at 3:30 AM to my cat moving from cuddling near my chest, to cuddling my womb. It was a very intentional move on her part to shift there, and I didn’t think anything of it till I felt a period-like cramp. I got up to go to the bathroom, and while I was peeing, I felt a tiny little pop and out came some drops of blood and a good chunk of my mucus plug! I woke up my husband and told him “I think this is it,” got myself a snack & coconut water, and decided to try to go back to bed. I kept feeling that really uncomfortable period-like cramping, which made it impossible for fall back asleep.
At 4:10 AM, my water broke. I felt a tiny gush and then proceeded to start leaking. After some time, the contractions were way too uncomfortable to sleep in-between, or even lie down in-between, no matter how hard I tried. I used a heating pad to try to bring relief. I knew this was labor & I really wanted to get rest in the early stage.
At some point, I was having to focus entirely on my breathing & I stopped being able to stand or sit through the contractions, and had to get on hands & knees to work through them. I was having to vocalize through them & could no longer have normal conversation in-between. I insisted to my husband a few times that I was in active labor and needed to go to the birth center, but the contraction app kept saying that I was only in early labor, because my contractions only lasted about 30-45 seconds, even though they were approximately 3min apart. Finally, I hit a point where I needed to get in the shower to get some relief from the contractions. I told my husband that I didn’t care what the contraction timer said, I needed him to call my midwife and we needed to go to the birth center. So he called her, packed up the car, and we left.
As soon as I got to the birth center and got into the room, I immediately had to go down on hands & knees again for another contraction. My midwife checked baby’s heart rate, my vitals, and checked for dilation. 4 CM. It was so empowering knowing that despite the contraction timer telling me I was only in early labor, I trusted my body and my intuition & I was indeed in active labor! My midwife said she was glad I came in when I did.
I ideally wanted a water birth, but my midwife said that we should wait for the tub until a little later on, when my contractions were feeling more intense. So I worked through contractions by leaning over the bed. I used a comb, focused on my breathing, and moved my hips & had low tone vocalizations. Eventually as they got stronger, I went into the shower.
My husband made me a little make shift bed in the shower with towels & knee mats so I could lay down in-between contractions & try to find some rest. I had no real concept of time during labor, so I have no idea how long I stayed in there. At some point, my midwife decided based on how I was vocalizing & acting during contractions that it was time to fill the tub up.
Some of the contractions were incredibly intense. I couldn’t stay still through my contractions - I had to move around with each one. My midwife commented that it was like I was dancing through labor because of my constant movement! At the end of every contraction, it felt like I had just completed a super intense work out. I was feeling really tired. I tried to have some coconut water and little bites of food to keep up my energy.
Getting in the tub felt so good. We had some moments of laughter in-between contractions when the birth assistant multiple times accidentally sprayed us with water when trying to finish filling up the tub. I loved that despite the intensity of labor, it was really such a joyful and peaceful and non-stressful environment.
Eventually I had a noticeable emotional shift (started crying a lot), and that, combined with the level of intensity of contractions, made everyone think I was in transition. My midwife had not checked my dilation since arriving at the birth center (I had declined), but based on how I was acting/the noises I was making during contractions, she encouraged me to start playing around with pushing.
I loved the feeling of the water but my husband noticed & commented that it definitely limited my movement. My midwife agreed and encouraged me to get out of the tub. I went to a birth stool and tried to push, but my body physically would not. I even remember saying, “I don’t know how to push, I don’t understand.” I kept insisting that my body could not do it, and I was so discouraged. My midwife asked again if I wanted to be checked to see if I was actually past transition, and this time I agreed. When she checked, I was only 7-8 CM, so not fully dilated. No wonder I couldn’t push! Once again, I felt validated knowing I could trust my body, and my intuition about my body not being through transition & not being ready to push was correct.
During transition, this is where my memory gets fuzzy. I was deep in labor land. Contractions were like waves crashing over and over me again, and I felt like I couldn’t come up for air sometimes because of how close together they were. I know I went back to the shower for awhile, and eventually made my way onto the bed. I had every intention of getting back in the tub (I think they even filled it up again for me) but I didn’t ever make it off that bed. I was making intense primal noises, grunting/screaming, & moving so much during each contraction. I broke the comb I was holding, I was knocking things over, ripping the covers on the bed - and not fully being aware of any of it. I remember thinking that I was envious of people who got epidurals and didn’t have to deal with transition. I reminded myself, “the only way out is through,” and “all this intensity is coming FROM you, it’s not something bad happening TO you.”
(Continued in comments)
submitted by Emotional-Disaster45 to BabyBumps [link] [comments]


2023.06.09 04:32 ELITER_Packaging Primary, Secondary, and Tertiary Packaging: What are the Differences?

Primary, Secondary, and Tertiary Packaging: What are the Differences?
Packaging is an essential aspect of product delivery and marketing. It plays a vital role in protecting products from damage, preserving their quality, and promoting their brand image. There are three main types of packaging: primary, secondary, and tertiary. In this article, we will discuss each type of packaging and its importance in the product distribution process.

Primary, Secondary and Tertiary Packaging

Primary Packaging

Primary packaging is the first layer of packaging that comes into direct contact with the product. It is the most critical packaging as it protects the product from physical, chemical, and biological hazards. The primary package is also responsible for maintaining the product's freshness, flavor, and aroma. Primary packaging can be made from various materials such as glass, plastic, metal, or paperboard, depending on the product's nature and intended use.
The primary package must fit the product perfectly to prevent leakage, contamination, or breakage. It must also provide clear information about the product's contents, usage instructions, and any safety warnings. The design of the primary package should be attractive and eye-catching to attract customers' attention and differentiate the product from competitors.

Primary Packaging
Examples of primary packaging include bottles, jars, tubes, pouches, cans, and blister packs. Each type of primary package has its advantages and disadvantages. For instance, glass bottles are elegant and preserve the product's flavor, but they are fragile and heavy. Plastic bottles are lightweight and shatterproof, but they may affect the product's taste and quality.
In summary, primary packaging is crucial for protecting the product and conveying vital information to the consumer. The right choice of primary packaging material and design can significantly impact the product's success in the market.

Secondary Packaging

Secondary packaging refers to the outer layer of packaging that holds the primary packages together. Its primary function is to facilitate the handling, transportation, and storage of the products. Secondary packaging can also provide additional protection to the primary package and enhance the product's aesthetic appeal.

Secondary Packaging
The secondary package is typically made from cardboard, paperboard, or corrugated fiberboard. It can take various forms, such as boxes, cartons, trays, sleeves, or wraps. The design of the secondary package should be sturdy enough to withstand rough handling during transportation and storage. It should also be easy to open and dispose of, without damaging the primary package or the product inside.
Secondary packaging plays a critical role in branding and marketing. It is often the first point of contact between the customer and the product. Therefore, the design of the secondary package should reflect the product's brand image, values, and target audience. It should also provide essential information about the product's features, benefits, and usage instructions.
Examples of secondary packaging include retail boxes, multipacks, shipping cartons, and display cases. Each type of secondary package has its unique features and benefits. Secondary packaging can be automated by packaging machines by eliter-packaging.com, which is a manufacturer of versatile secondary packaging equipment. For instance, retail boxes are designed to attract customers' attention on store shelves and promote impulse buying. Multipacks offer convenience and value for money to customers who need to buy products in bulk.
In summary, secondary packaging is crucial for facilitating the handling, transportation, and storage of products. It can also enhance the product's brand image and marketing appeal.

Tertiary Packaging

Tertiary packaging refers to the outermost layer of packaging that protects the products during distribution and logistics. Its primary function is to ensure the safe and efficient delivery of the products from the manufacturer to the retailer or end-user. Tertiary packaging is usually made from robust materials such as wood, metal, or plastic. It can take various forms, such as pallets, crates, containers, or bags.

Tertiary Packaging
The design of tertiary packaging should consider the specific requirements of the supply chain, such as weight, size, and stacking capacity. It should also comply with international shipping standards and regulations to avoid delays, damages, or losses. Tertiary packaging can also provide additional protection to the products from weather, theft, or tampering.
Tertiary packaging is essential for reducing logistics costs and improving supply chain efficiency. It enables manufacturers to transport large volumes of products in a single shipment, reducing the number of trips required and minimizing fuel consumption. Tertiary packaging can also facilitate the handling and storage of products in warehouses and distribution centers, saving time and labor costs.
Examples of tertiary packaging include pallets, crates, bulk containers, and shrink-wrapped bundles. Each type of tertiary package has its advantages and disadvantages. For instance, pallets are cost-effective and easy to handle, but they require additional protective wrapping to prevent damage during transit. Bulk containers offer maximum volume and protection, but they are more expensive and difficult to handle than other types of tertiary packaging.
In summary, tertiary packaging is crucial for ensuring the safe and efficient delivery of products from the manufacturer to the end-user. It can reduce logistics costs and improve supply chain efficiency while providing additional protection to the products.

Difference between Primary Packaging and Secondary Packaging

Primary packaging and secondary packaging are two different types of packaging used for products.
Primary packaging is the first layer of packaging that comes into direct contact with the product. It is designed to protect, contain, and preserve the product during transportation, storage, and handling. Primary packaging can be made from a variety of materials such as plastic, glass, metal, or paperboard. Examples of primary packaging include bottles, jars, tubes, cans, and pouches.
Secondary packaging, on the other hand, is the outer layer of packaging that surrounds the primary packaging. Its purpose is to provide additional protection, branding, and convenience for consumers. Secondary packaging can also be used to group several primary packages together for easier handling and transportation. Examples of secondary packaging include cardboard boxes, shrink wrap, and blister packs.

Difference between Primary Packaging and Tertiary Packaging

Primary packaging, also known as the first-level packaging, is the packaging that directly encloses the product. It is the layer of packaging that is in direct contact with the product and is designed to protect, preserve, and contain it. Examples of primary packaging include bottles, cans, jars, blister packs, and bags.
On the other hand, tertiary packaging, also known as the third-level packaging, is the packaging that is used for transportation and handling of the products. It is designed to protect the primary and secondary packaging during shipping and distribution. Tertiary packaging can include pallets, crates, boxes, and other containers used for bulk transport.
In summary, primary packaging is the packaging that directly holds and protects the product, while tertiary packaging is the packaging that is used to transport and handle multiple units of the product. The secondary packaging, which is also called the second-level packaging, refers to the packaging that groups several individual units of a product together

Difference between Secondary Packaging and Tertiary Packaging

Secondary packaging, also known as the second-level packaging, is the packaging that holds together multiple units of a product for retail display or sale. It is designed to protect and contain the primary packaging during distribution and handling. Examples of secondary packaging include cardboard boxes, shrink wrap, and display trays.
Tertiary packaging, on the other hand, is the packaging that is used for transportation and handling of products in bulk quantities. It is designed to protect both primary and secondary packaging during shipping and distribution. Examples of tertiary packaging include pallets, stretch wrap, and shipping containers.

In the END

In conclusion, primary, secondary, and tertiary packaging are essential components of product distribution and marketing. Each type of packaging plays a unique role in protecting the product, facilitating its handling and transportation, and promoting its brand image. The right choice of packaging material and design can significantly impact the product's success in the market. Therefore, manufacturers should carefully consider their packaging needs and options to ensure the best outcomes for their products and customers.
submitted by ELITER_Packaging to u/ELITER_Packaging [link] [comments]


2023.06.09 04:29 Bubzoluck [30 min read] The Opioid Epidemic before the Opioid Epidemic - Exploring Morphine Derivatives and the First Opium War (Part 1)

[30 min read] The Opioid Epidemic before the Opioid Epidemic - Exploring Morphine Derivatives and the First Opium War (Part 1)
Hello and welcome back to SAR! I have written and rewritten this post a few times now and I think I have landed on a format I am happy with. When we talk about the impact of medicine on history its important to get the context right, and I think I have found a way to talk about our topic. So what is it? No chemical is more important to the world of medicine than Opium, okay maybe Penicillin, but today we will say its Opium. Principally an analgesic (anti-pain), the Opium Poppy allowed for humans to take away pain in great degrees and further development on the natural chemicals has opened up surgery and post-op recovery. While we tend to look at the recent Opioid Epidemic as the only issue regarding Opiates, history reveals to us a very similar precursor. Also please head over to u/jtjdp post about morphine derivatives here! She does an amazing job explaining the higher level concepts of medicinal chemistry that I just wouldn’t do justice. Alright, enough quibbling, let’s get to the good stuff.
Disclaimer: this post is not designed to be medical advice. It is merely a look at the chemistry of medications and their general effect on the body. Each person responds differently to therapy. Please talk to your doctor about starting, stopping, or changing medical treatment.

How Much do you Know About Pain?

To be alive is to feel pain, and emo sentiments aside, this is one of the biggest biological properties of the central nervous system. When you think about it, how does the body take external stimuli and allow you to recognize it? The answer is the sensory nervous system which is responsible for sensing many different types of stimuli: temperature, pressure, pain, and chemicals. These sensory neurons carry the information from the extremities and transmit it up the spinal cord into the brain for processing. From there the brain alerts you to the issue allowing you to correct whatever problem is causing the pain. Let’s take a look:

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  • We call these receptors Nociceptors and activation of these neurons in the periphery leads to a signal being sent towards the spinal cord. Those peripheral nerves eventually complex with the Dorsal Horn of the spinal cord and interface with the central nervous system to transfer the pain signal. This signal is then sent Ascending to the Thalamus where the pain signal is recognized and initiates a response (such as pulling your hand away from the hot stove). But that’s not the full story, the brain also sends signals back down Descending to modify the incoming signal and dampen it. Its this modifying that makes pain fade over time when you aren’t focusing on it—otherwise the brain would be overwhelmed by the repetitive signal and continuously think injury is still happening. Now let’s divide this process into its two parts, first up the Ascending pathway.

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  • As the Action Potential travels from the periphery towards the Spine it causes the influx of Calcium into the Presynaptic Neuron. This neuron is what carries the original signal to then transfer into the Spine for further traveling. Eventually we reach the Synapse where the finger-nerve and spine meet and we get the transfer of information via Neurotransmitters. In this case, two chemicals are released: Glutamate and Substance P (which literally stands for Substance Pain). Glutamate will activate two receptors (AMPA and NMDA) which are Excitatory and stimulate the continuation of the pain signal up to the brain. Substance P activates the NK1 receptor which enhances the frequency of the pain signal (the throbbing) and the intensity of the pain burst. So to simplify, Glutamate allows the signal to be passed up to the brain but depending on the strength of the original pain signal more or less Substance P is released which modulates the strength and attention-grabbing nature of it. Okay great, we sent the pain pathway up and it will get processed in multiple different parts of the brain. But the brain can’t have that signal stinging it so it must send information back down to dampen that pain signal. This is where that aforementioned Descending pathway comes in. Above you can see how the blue line reaches down out of the brain and back into the spine to turn ‘off’ the signal. This is the basis of Analgesia or pain relief.

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  • Okay so now we have to divide the action of the Descending pathway which acts to dampen and modulate the original signal coming into the brain. Now, normally at rest this Descending neuron is inhibited so any fresh incoming signal is not inhibited from the get go but once that pain signal does come in, we get the good stuff! In response to pain the brain releases substances called Endorphins which activate the mu Opioid Receptor (MOR) located on the Descending pathway. Now MOR are inhibitory in nature so they are inhibiting the inhibitory resting state of neurons, or in other words, are allowing the Descending neuron to activate. And this is an important fact to recognize, Opiates do not inhibit pain, they inhibit the physiology of the nervous system that prevents modulation of the pain signal.
    • Once the inhibition is inhibited, the Descending neuron is free to release two neurotransmitters onto the nerve that was carrying the original pain signal. Both Norepinephrine and Serotonin are released to activate their respective receptors which inhibit the release of Substance P and Glutamate thus decreasing the incoming pain signal. Likewise MOR receptors are found directly on the incoming nerve and further prevent the release of Glutamate and Substance P as well as being found on the Ascending neuron preventing the activation of the NMDA/AMPA and NK1 receptors. The result: dampened incoming signal and decreased pain sense being sent to the brain.

The Stars Align in the Shape of a Poppy


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To start our story about Opiates we need to turn to the great precursor—Opium. Opium itself is not a chemical but rather a really thick liquor (called latex) that contains a high concentration of Morphine (and some Codeine). There are 38 species of Poppy plants but only two produce Opium is great enough supply that it is worth farming them and humans have been cultivating these varieties for as long as we have known about the plants. When humans settled into Mesopotamia (near modern day Iraq), Poppies were one of the few plants grown in plots as large grain or vegetable fields (meaning that they were thought of as valuable as food). Throughout the Greek age of medicine (pre-500 BCE) through the Islamic medicinal revolution (500 BC-1500 AD), Opium was a major component of treatment, assisted suicide, and poison. In fact its through the rise of the Muslim Caliphates that we see the export of Opium to other parts of the world, especially through the Mediterranean Sea once the Crusaders return. Opium trading to the East via the silk roads was an almost continuous affair since time immemorial and Pakistan was a major growing area for the Eastern Poppy trade.
  • By the time after the Crusades (11-13th centuries), we start to see the West’s fixation on Opium. For many reasons Europe didn’t develop many psychoactive plants to the same degree as more humid/hot climates like Africa, the Middle East, and India. This is why the importation of Opium (and also Marijuana) was such a trade commodity and staple in the development of Western medicine. During the Renaissance and the revival of Greek philosophy we start to see the re-fascination with Opium and by the 1600s we see merchants importing Laudanum into Europe for recreational and medicinal use. The standard use of Tincture of Opium (which is Opium dissolved in ethanol, a DEADLY combination) was a particularly favorite preparation which was prescribed to the lowest day-worker all the way up to kings.
    • The importation and use of Opium exploded in the late 1700s once the British conquered a major Poppy growing region of India. This region (western India and most of Pakistan) was originally slated to grow cotton like the American colonies but the region wasn’t wet enough to sustain the plant—it could however grow copious fields of Poppy plants to create Opium. Throughout the 18th century the British Raj became the largest exporter of Opium to Europe and after the discovery that Mercury and Arsenic may not be safe, Opium took over their duties. By 1780 almost all major remedies incorporated the use of Opium in some capacity and with the huge supply, it was incredibly cheap.

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  • Poppy wasn’t only important to the British for its medicinal properties but also to bolster the huge amount of loss they were incurring in global trade to one trade partner—China. After she made contact with China in the mid-1500s, Britain starting to import HUGE amounts of tea as the Brits became literally addicted to the substance. By 1800 a full 15% of the ENTIRE British Empire’s revenue was being spent on importing tea, that’s 30 million pounds per YEAR, leading to a massive trade deficit. This means that more money was being sent to China literally enriching a foreign country while the British public was getting their fix on the black stuff. Oh and just in case you think things haven’t changed, Britain still accounts for 42.6% of the world’s tea consumption—seriously Brits, ever heard of coffee? Anyways, all this money leaving the British economy to be spent on non-Empire sustaining commodities was a major national security risk for the British. It would be different if they were importing gunpowder like the Dutch were or Silver as the Spanish had but literally they were consuming the riches they were spending the money on.
    • Remember too that the British were not in the best position by the turn of the 19th century—they had just lost their colonies in the Americas, involvement in the Napoleonic Wars killed a generation of men, and the push to develop industries over public health led to a focus on fast growth rather than smart growth. One of the results of the Napoleonic Wars was the British occupation of the Island of Java which developed a very potent Opium which was traded with Chinese merchants regularly. Soon British merchants realized they could rebalance the trade deficit by selling Javanese Opium into China but the small island was unable to produce enough Poppies to meet the demand. So Britain turned to another one of its colonies, India.

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  • India by the end of the 1700s was a bit of a challenge. The British hold on the subcontinent was firm but they couldn’t grow the cash crops they wanted. Indian cotton was nothing compared to Egyptian or Southern American (i.e. Virginia/North Carolina/Georgia) cotton and the Indian tobacco was known for being bitter. But by the 1770s the British government realized that Poppy was an easy crop to grow and the demand across the border with China was an easy market; British traders brought their cargo to small islands off the coast of China where it was sold for silver. Initially the Chinese didn’t mind the sale of Opium in their territory—when the British traders collected the silver from the sale they would almost immediately use it to buy Chinese goods, thus driving tax revenue for the Chinese government.

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  • But if you buy Opium, people are going to use that Opium. By the 1810s all trade with foreigners was restricted to just one port, Canton, and slowly the city started to develop a habit for the drug. The use of mind altering substances was curtailed pretty quickly for hundreds of years in China—the Ming Dynasty banned tobacco in 1640 and the Qing banned Madak (a powdered Opium containing tobacco) was similarly banned in 1729. But by 1790 more and more Chinese citizens were becoming addicted to the substance; what started as a recreational drug slowly became a crippling addiction that took hold over Canton. For a rigid society, the crippling Opiate addiction was a moral corruption for the Qing government and forced them to curtail Opium importation in 1780 and then an outright ban in 1796.

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  • Knowing just how devastating the Opium was having on the inhabitants of Canton, as well as how it spread further inland, British merchants kept peddling their drug. Older ships with larger hulls were converted into floating warehouses and parked just outside of navigable waters. Once set up, Opium smugglers would pull up, purchase the Opium and avoid any oversight by the Chinese government to prevent the sale of the drug. Following their mother country, American merchants started to sell Turkish Opium, an inferior variety, at a much cheaper rate leading to drug peddling competition with more and more tons of Opium being sent into China. This drove down the price of Opium considerably which ultimately increased the demand.
    • This demand eventually led to reversal of trade, meaning that more silver was leaving China to pay for Opium than the British were using to pay for Chinese goods. American and European traders could show up in Canton with holds full of Opium, sell it off for a profit, and then make a tidy silver profit to bring back to Europe. Likewise the importation of cheap machine-made cotton, furs, clocks, and steel into China driving down domestic profits.

Let’s Look at the Drugs a Bit


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Stepping away from the history a bit, let’s introduce the Family. Okay so we understand how pain is sent to the brain and how it modulates but there is so much more to the mu Opioid Receptor and that’s not the only kind of Opioid receptor that we have. The two most clinically useful receptors are the Mu and Kappa Opioid Receptors (KOR) because they result in analgesia but there is a Delta Opioid Receptor (DOR) that is worth mentioning. The majority of the Opiates that we know and love are Mu agonists but there are some very interesting Kappa agonists that are worth mentioning as well.

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  • Above is a chart that shows the binding affinities of select Opiates to the Mu receptor. The smaller the number is, the more tightly they bond. Now affinity is different than potency—potency is a measure of how much drug (in g) is required to produce the same effect. So even though morphine has a higher affinity than fentanyl, fentanyl has a MUCH more potent effect (which is why it can be so dangerous, you only need a little). Now many of the opiates cause the same effect so I want to spend more time on what makes them all so different:
  • First up we have the 5-Ring Morphinians which are derived from the natural product Morphine. These structures have 5 component parts: an aromatic benzene ring (A), a completely saturated bridge ring (B), a partially unsaturated ring with an alcohol attachment (C), a piperidine heterocycle above the rest of the structure (D) and finally a ether linkage between the top and bottom of the structure to keep it fairly rigid (E). Truthfully we are only going to focus on two locations—firstly the top alcohol (red circle) can be methylated to form Codeine, a natural Prodrug of Morphine. A Prodrug is one that is biologically inactive but goes through an initial metabolism once ingested that makes it active.

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  • In fact it’s this initial metabolism of Codeine that makes it very interesting. In order for Codeine to exert any pain relief it needs to be converted to Morphine which actually exerts the desirable properties. This is done by the liver enzyme CYP2D6 which is a pretty minor pathway for Codeine—only about 10% of the Codeine is actually converted to Morphine to have some action. Because of this 2D6 dependent pathway we have to be careful about administering drugs that might inhibit the 2D6 pathway because that would mean we are preventing codeine from being active. Drugs like Fluoxetine (Prozac) and Paroxetine (Paxil) are strong 2D6 inhibitors and so if we administered Codeine to someone taking this drug they’d never get any benefit from the Codeine. In addition there are genetic/ethnic differences that pharmacists can account for such as 2D6 activity. If you are someone with very little 2D6 activity then you would also not convert Codeine to Morphine and thus get no action from the drug—this may be a reason why some people say Codeine doesn’t work for them. Another reason could be that they are Rapid Metabolizers and quickly convert the Codeine to Morphine and thus get a massive hit quickly after ingestion—in that cause you’d need a much smaller dose than another person for the same effect.

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  • A different drug that is the opposite of Codeine is Hydromorphone (Dilaudid) which has a Ketone on ring C. This ketone and the lack of the double bond on this ring increases the lipophilicity of the drug and increases its ability to penetrate into the brain and thus have a greater effect. In fact Hydromorphone is 5-10x more potent than Morphine due to its greater ability to penetrate into the brain and increased receptor affinity for the mu receptor. Because the A ring OH is not capped with a methyl group, we don’t need to rely on 2D6 to metabolize Hydromorphone into an active drug form which again increases the activity of this drug compared to Codeine.
  • So combine these two structural changes—the capped OH on ring A as seen in Codeine and the increased affinity found with the ketone in Hydromorphone and we get Hydrocodone (Norco, Lorcet). Well in this case you’d get a drug that has very good affinity for the mu receptor (better than codeine) BUT is still reliant on the small 2D6 pathway for activation (worse than morphine). In this regard only about 10% of Hydrocodone is active at a time. We can see this effect in the relative doses for equivalent effect: to match the effect of 30mg of Morphine, we’d need only 7.5mg of Hydromorphone (more active) but need 200mg of Codeine (less active).

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  • This brings us to our last drug of this class, Oxycodone which has a special OH group found on Ring B. What you’ll notice is that Oxycodone has that capped OH on ring A so it requires metabolism through 2D6 just like Codeine and Hydrocodone. When it is uncapped it becomes Oxymorphone which has 3 times as much effect as Morphine BUT that extra OH makes Oxycodone an exclusive Mu receptor agonist. Unlike the other drugs which may go to other receptors causing side effects (more on this later).

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  • Next up I want to look at some Mu opioid receptor Antagonists or those than inhibit the function of the opioid receptor. Looking at the first two drugs, Naloxone and Naltrexone, we can see that they have the structure similar to Hydromorphone so they would have incredible brain penetration and affinity for opioid receptors BUT they contain that funky Nitrogen tail. Now normally there is a short methyl tail that is required for the function of Morphine but by adding a bulkier tail the drug is able to fit inside the receptor but prevent activation. What’s most important about these two drugs is that they have much more affinity for the receptor than other opiates. We can see this effect in the graph above: when no Naloxone is present, Fentanyl occupies the opiate receptor about 75% of the time. But as soon as Naloxone is administered that number drops swiftly (within minutes)--this is because Naloxone has a higher affinity for sitting in the receptor than Fentanyl. Think of it like the bully Naloxone coming up and pushing the poor defenseless Fentanyl off the swings so the bully can play on it (except in this instance Fentanyl is causing an overdose and we need to save someone’s life).

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  • Buprenorphine is similar but it is a Partial Agonist instead of being a full antagonist. Buprenorphine is not a 5-ring Morphinian byt a 6-ring Oripavine that has a few different modifications. The biggest additions is that it has the bulky Nitrogen tail found in full Antagonists but it has this funky C ring tail which fights the antagonism. The result is a tug of war between the antagonism of the Nitrogen tail and the agonism of this new C-ring tail resulting in Partial agonism—so if you took Buprenorphine you’d notice a markedly decreased pain relieving ability but importantly there is a ceiling effect, its much harder to overdose on Buprenorphine than other full agonists. In addition in the second graph we can see that Buprenorphine has the greatest affinity for the receptor than our other agonists which prevents someone from taking a more potent opiate while taking Buprenorphine. In this case the bully is already sitting on the swing and scaring away the other kids thus preventing them from having a turn (and potentially causing an overdose). This does mean that if someone was taking a more potent drug (like Fentanyl) and then took Buprenorphine, it would cause withdrawal just like Naloxone or Naltrexone.

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  • Speaking of withdrawal, let’s take a look at how that happens. Remember that the pain signal is caused by the activation of AMPA and NMDA receptors from the peripheral nerve. AMPA is a type of receptor called a G-Protein Coupled Receptor or GPCR which in this case is linked to an Excitatory G-protein which leads to the activation of the nerve. When AMPA is activated, the G-protein (Ga) activates an enzyme called Adenylate Cyclase (AC) which increases the production of pro-activity cAMP—or in simpler terms—when AMPA is activated, it leads to an increase in levels of pro-pain molecule cAMP. The Opioid receptor is also a GPCR but it is linked to an inhibitory G-protein which prevents the action of Adenylate Cyclase and thus leads to a decrease in cAMP levels. So Opiates prevent pro-pain cAMP signaling from continuing.
    • In the second graph we can see how tolerance forms. Initially (A), Adenylate Cyclase and cAMP levels are not affected by having opiates even though their ability to push along the pain signal is blocked. After a few hours, the leftover cAMP is degraded and cAMP levels start to drop significantly (B). In response to these levels going down, the activity of Adenylate Cyclase starts to increase and increase (C) which raises the level of cAMP. This rise in Adenylate Cyclase activity opposes the action of the opiate which necessitates the need for increased doses of Opiates and is why tolerance forms. As sustained inhibition of Adenylate Cyclase continues, the body upregulates Adenylate Cyclase activity to create more cAMP and to combat this we increase the dose.
    • Now what if after years of taking an Opiate we suddenly administer Naloxone, an Opiate antagonist. Well after weeks to months of taking an Opiate, the level of Adenylate Cyclase activity is WAY above baseline. When you administer the antagonist, suddenly Adenylate Cyclase is able to produce a TON of cAMP that normally is blocked which leads to a MASSIVE amount of downstream signaling. The result is intense nausea and vomiting, stomach cramps, fever, anxiety, insomnia, and cravings. Thankfully the withdrawal process ends after about 72 hours but is one of the worst experiences someone can go through which is why proper down-tapering of Opiates is extremely important.

A Change in Trade Policy


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Oh, you’re still here. Neat! So by the 1820s the Qing dynasty was running into many problems regarding Opium. Firstly they needed the Opium taxes to fund their efforts to put down the White Lotus Rebellion and retain power. But after almost 30 years of trade the effects on Chinese communities could not be ignored along with local officials operating under the imperial trade department, the Hong, profiting from bribes to allow Opium. Regardless of initial efforts things were getting out of hand for the Qing government. In 1800, about 4000 chests of Opium or 560,000 pounds entered the country but by 1830 that number exploded to 20,000 chests or about 3 million pounds. But more than the amount of Opium actually entering the country was the incessant rudeness of the British government to open trade.
  • One of the “problems” for the British traders was how clamped down trade was with China. By 1800 all trade was limited to just Canton and the Hong was a strict master of trade. Foreigners were not allowed to appeal decisions made by the Hong and only Chinese traders could sell goods further inland than Canton. Traders chafed against this extreme oversight and sent hundreds of letters to the Hong requesting special dispensations which were summarily denied. Things changed significantly in 1834 when the Chinese trade was de-monopolized away from the East India Company allowing any private trader to get involved in the Eastern trade.

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  • In August of 1834, the British sent Lord William John Napier to Macau as superintendent of Chinese trade with the explicit order to follow all Chinese regulations. Thinking he knows best, Napier decided that the restrictive Chinese trade system was too restrictive and sent a letter to the Viceroy of Canton. This was unheard of—NO foreign traders were allowed to speak directly with Chinese officials and the Viceroy refused to accept it. So why not double down by ordering two British ships to BOMBARD two Pearl River forts as a show of force? Luckily Napier died of Typhus almost directly after else it would have resulted in a full blown war.
  • In 1839 the Qing government appointed Lin Zexu as the Opium czar to completely eradicate the Opium trade from China. Lin banned the sale of Opium in China completely, set up rehabilitation centers for those affected by the drug, and put addicts to work to distract them while detoxing. Lin demanded that all Opium supplies must be surrendered to Qing authorities and any Chinese citizen disobeying the order would be punishable by death. He even went as far as closing the Pearl River Channel, trapping British traders in Canton and seizing their Opium warehouse stockpiles.
  • The replacement for Napier was Admiral Sir Charles Elliot who protested the seizure of the Opium stockpile but knew that they could do nothing. He ordered all Opium ships to flee and prepare for battle which caused Lin Zexu to beseige a group of traders inside a Canton warehouse. Elliot convinced the traders to cooperate with the Chinese government and surrender their stock, saying that the British government would compensate for the lost Opium (which he had no authority to do). During April and May 1839 the British (and American) traders to surrender 20,000 chests of Opium which was burned for three days outside Canton. Following the burning, trade resumed to normal except no more Opium was allowed. Like many other instances of the government removing legitimate sale of a drug, the black market increased markedly.
  • In July 1839 a new scandal rocked the British-Chinese trade system; two British sailors became drunk and beat a man death outside of his village. In response, Superintendent Elliot arrested the two men and paid compensation to the villager’s family for the loss of the man but Elliot refused to hand over the sailors to the Qing government. Lin Zexu saw this as a blatant disregard for Chinese law—afterall traders needed to understand that they can’t just come to China and violate Chinese law as they saw fit. Elliot offered to hold a trial on a British ship in front of Chinese officials to show that the men would not get off free. This incident would start the smoldering.
    • On September 4th, Elliot sent two ships to Kowloon to buy food and provisions from Chinese peasants. While approaching the harbor, three Chinese war junks gave permission to the two British ships to trade but that permission was rescinded by the commander of Kowloon fort. Elliot fumed against the slight and said that if the British were not allowed to trade by 3pm, he would fire on the fort. 3pm passed and the British opened fire on the fort causing the Chinese junks to return fire. The fighting continued for 7 hours until nightfall and Elliot had to prevent the British officers from pressing the attack, thus ending the Battle of Kowloon. Having driven off the Chinese ships, the British purchased the supplies they needed while the Kowloon commander claimed that both ships were sunk and 50 British sailors killed.
    • The reaction in Britain was about as much as you expect. Prime Minister Palmerston sent out letters to the Governor General of India to prepare marines to invade China and another letter to the Chinese Emperor telling him that Britain would send a military force. He sent a letter to Superintendent Elliot to set up a blockade on the Pearl River and capture Chusan Island. He also instructed Elliot to accomplish the following objectives:
      • Demand the respect as a British envoy from the Qing Government.
      • Secure the right for British law to be doled out on British subjects
      • Get recompense for destroyed British property, especially the illegal drugs that they destroyed
      • And most important, End the Canton System thus opening up China to free trade for the first time, ever.
Alright this is where we will leave things off for now, on the brink of war with China. Stay tuned!
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